{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:13:17Z","timestamp":1791688397273,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3633,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1996,1]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To determine the frequency and clinical characteristics of diffuse distal extremity swelling with pitting edema occurring in polymyalgia rheumatica (PMR).<\/jats:p>Methods<\/jats:italic>. Clinical features and laboratory findings were recorded for all 245 residents of Olmsted County, Minnesota who developed PMR over a 22\u2010year period (1970\u20131991). Those who exhibited \u22651 episode of diffuse distal extremity edema with pitting were selected for this study, and were evaluated further.<\/jats:p>Results<\/jats:italic>. Thirteen women and 6 men in this incidence cohort of PMR had \u22651 episode of distal extremity swelling with pitting edema. Giant cell arteritis was also identified in 5 patients. In 11 patients, the swelling and edema developed concurrently with proximal PMR symptoms. In 2 patients, the distal swelling was the initial manifestation, and in 6 patients, the distal symptoms developed during relapses or recurrences of PMR. Both upper and lower extremities were affected, usually in a symmetric manner. Other peripheral manifestations were also common. The distal swelling and pitting edema responded promptly to corticosteroids, and slowly or incompletely to nonsteroidal anti\u2010inflammatory drugs; a similar response was observed in the proximal symptoms. The distal swelling appeared to represent tenosynovitis and synovitis of regional structures.<\/jats:p>Conclusion<\/jats:italic>. Distal extremity swelling with pitting edema represents a manifestation of PMR that has not been well described in previous studies. Awareness of this finding will help facilitate the proper diagnosis and institution of appropriate therapy for this disease.<\/jats:p>","DOI":"10.1002\/art.1780390110","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:53:26Z","timestamp":1171454006000},"page":"73-80","source":"Crossref","is-referenced-by-count":82,"title":["Distal extremity swelling with pitting edema in polymyalgia rheumatica. Report of nineteen cases"],"prefix":"10.1002","volume":"39","author":[{"given":"Carlo","family":"Salvarani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene G.","family":"Hunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-672"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90012-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240706"},{"key":"e_1_2_1_5_2","first-page":"205","article-title":"Polymyalgia rheumatica and giant cell arteritis: a 5\u2010year epidemiologic and clinical study in Reggio Emilia, 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