{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:27:33Z","timestamp":1791300453713,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1996,4]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To establish a simian model of human T lymphotropic virus type I (HTLV\u2010I) infection and disease.<\/jats:p>Methods<\/jats:italic>. Irradiated HTLV\u2010I\u2013producing cells were used to infect two 2\u2010year\u2010old rhesus macaque monkeys (Macaca mulatta<\/jats:italic>). One monkey was also simultaneously inoculated with a cell\u2010free suspension of simian immunodeficiency virus (SIV). Evidence of infection was monitored by serial clinical examinations and by serologic, molecular, and virologic assays.<\/jats:p>Results<\/jats:italic>. Both HTLV\u2010I\u2010inoculated monkeys became persistently infected following inoculation. Clinical disease was observed in the singly inoculated monkey, which developed arthritis (with synovial fluid positive for HTLV\u2010I by culture and polymerase chain reaction), anterior chamber uveitis, and steroid\u2010responsive polymyositis confirmed by electrophysiologic studies. The dually inoculated animal remained clinically healthy, despite high levels of SIV and HTLV\u2010I virus expression and loss of HTLV\u2010I\u2010specific antibodies.<\/jats:p>Conclusion<\/jats:italic>. These results indicate the utility of a nonhuman primate model for studying HTLV\u2010I disease pathogenesis and the dynamics of SIV\u20101\/HTLV\u2010I retroviral coinfection.<\/jats:p>","DOI":"10.1002\/art.1780390410","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:40:22Z","timestamp":1171453222000},"page":"610-615","source":"Crossref","is-referenced-by-count":22,"title":["Polymyositis, arthritis, and uveitis in a macaque experimentally infected with human T lymphotropic virus type I"],"prefix":"10.1002","volume":"39","author":[{"given":"Mark A.","family":"Beilke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Traina\u2010Dorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"England","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805053181801"},{"key":"e_1_2_1_4_2","first-page":"316","article-title":"HTLV\u2010I myelopathy, polymyositis and synovitis: an expanding rheumatic spectrum","volume":"19","author":"Sowa JM","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.4.943"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890380212"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380518"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.152.7.1429"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890440205"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500609"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904133201507"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130312"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140404"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252107"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1128\/jvi.66.4.2288-2295.1992","article-title":"Low degree of HTLV\u2010I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations","volume":"66","author":"Gessain A","year":"1992","journal-title":"J Virol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02123570"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780390410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780390410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T02:02:26Z","timestamp":1700704946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780390410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1002\/art.1780390410"],"URL":"https:\/\/doi.org\/10.1002\/art.1780390410","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}