{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:00:01Z","timestamp":1761843601684},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3542,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the efficacy of oral chicken type II collagen (CCII) in the treatment of juvenile rheumatoid arthritis (JRA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Ten patients with active JRA were treated with CCII for 12 weeks. Efficacy parameters, which included swollen and tender joint count and score, grip strength, 50\u2010foot walking time, duration of morning stiffness, and patient and physician global scores of disease severity, were assessed monthly.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. All patients completed the full course of therapy. Eight patients had reductions in both swollen and tender joint counts after 3 months of CCII. The mean changes from baseline in swollen and tender joint counts for the 8 responders at the end of the study were \u201361% and \u201354%, respectively. Mean values for other efficacy parameters also showed improvement from baseline. There were no adverse events that were considered to be treatment related.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Oral CCII may be a safe and effective therapy for JRA, and its use in this disease warrants further investigation.<\/jats:p>","DOI":"10.1002\/art.1780390413","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:40:22Z","timestamp":1171453222000},"page":"623-628","source":"Crossref","is-referenced-by-count":80,"title":["A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"39","author":[{"given":"Martha L.","family":"Barnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Combitchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Trentham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0889-857X(21)00889-9","article-title":"Epidemiology of the rheumatic diseases of childhood","volume":"16","author":"Singsen BH","year":"1990","journal-title":"Rheum Dis Clin North Am"},{"issue":"2","key":"e_1_2_1_3_2","first-page":"279","article-title":"Prognosis of juvenile rheumatoid arthritis","volume":"20","author":"Hanson V","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_4_2","first-page":"891","article-title":"Juvenile rheumatoid arthritis: outcome and treatment for the 1990's","volume":"17","author":"Wallace CA","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605153142001"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261602"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92627-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90853-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6688"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7443"},{"key":"e_1_2_1_11_2","first-page":"581","article-title":"Gastric administration of type II collagen delays the onset and severity of collagen\u2010induced arthritis in rats","volume":"64","author":"Thompson HSG","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.4049\/jimmunol.145.8.2489","article-title":"Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen","volume":"145","author":"Zhang ZY","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","first-page":"1321","article-title":"Effects of oral administration of type II collagen on rheumatoid arthritis","volume":"259","author":"Trentham DE","year":"1993","journal-title":"Science"},{"issue":"2","key":"e_1_2_1_14_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503283121303"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7680493"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10252"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.4049\/jimmunol.144.5.1689","article-title":"Inhibition of S\u2010antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S\u2010antigen","volume":"144","author":"Nussenblatt RB","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.5.1355"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.4049\/jimmunol.126.6.2079","article-title":"Simultaneous induction of antigen\u2010specific IgA helper T cells and IgG suppressor T cells in the murine Peyer's patch after protein feeding","volume":"126","author":"Richman LK","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7520605"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240926"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380811"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.4049\/jimmunol.147.7.2155","article-title":"Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy","volume":"147","author":"Whitacre CC","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.4049\/jimmunol.154.11.5649","article-title":"T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction","volume":"154","author":"Garside P","year":"1995","journal-title":"J Immunol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780390413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780390413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T02:02:44Z","timestamp":1700704964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780390413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1002\/art.1780390413"],"URL":"https:\/\/doi.org\/10.1002\/art.1780390413","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}