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BMC and BMD were measured by dual x\u2010ray absorptiometry in 41 children with JRA and 62 healthy children. Serum samples were analyzed for concentrations of minerals, vitamin D, parathyroid hormone, osteocalcin, bone\u2010specific alkaline phosphatase (BAP), procollagen I carboxy\u2010terminal propeptide, and tartrate\u2010resistant acid phosphatase (TRAP), and urinary excretion of deoxypyridinoline crosslinks and calcium.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. BMD was decreased at all sites in JRA patients. BMD, corrected for age, height, weight, and bone area, was decreased at cortical bone sites (1\/3 radius, upper and lower extremities, and whole body). Low concentrations of osteocalcin and BAP suggested reduced bone formation, and low TRAP levels suggested decreased resorption. Clinical scales of disease severity were negatively correlated with measures of bone mass. Laboratory markers of disease severity were highly correlated with decreases in markers of bone formation, but not with those of resorption. Although laboratory findings were similar for children with oligoarticular and polyarticular disease, differences in bone mass were greater in children with polyarticular disease.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. These data suggest an association between decreased bone mineralization in JRA and low bone formation that is related to disease severity. Efforts to stimulate bone formation, therefore, need to be considered clinically in prepubertal children with active JRA.<\/jats:p>","DOI":"10.1002\/art.1780390506","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:40:17Z","timestamp":1171453217000},"page":"746-757","source":"Crossref","is-referenced-by-count":112,"title":["Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"39","author":[{"given":"Peri Hickman","family":"Pepmueller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"Osteoporosis: diagnosis and management","volume":"38","author":"Hahn BH","year":"1988","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0889-857X(21)00348-3","article-title":"Epidemiology of osteoporosis","volume":"20","author":"Nevitt MC","year":"1994","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-7-516"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284051"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(91)90021-Q"},{"key":"e_1_2_1_7_2","volume-title":"Textbook of Pediatric Rheumatology","author":"Cassidy JT","year":"1995"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.5.377"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555248"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(90)90081-P"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83179-8"},{"key":"e_1_2_1_12_2","first-page":"1235","article-title":"Estimation of bone mineral density in children with juvenile rheumatoid arthritis","volume":"18","author":"Hopp RJ","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81605-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(06)80006-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82424-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_17_2","volume-title":"Growth at Adolescence","author":"Tanner JM","year":"1962"},{"key":"e_1_2_1_18_2","first-page":"109","article-title":"Standard methodology for segment I, II, III Pediatric Rheumatology Collaborative Study Group studies. 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