{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:25:33Z","timestamp":1790879133584,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3512,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To elucidate the role of antiendothelial cell antibodies (AECA) in vascular inflammation in patients with Wegener's granulomatosis (WG).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. IgG fractions from 3 AECA\u2010positive WG patients, IgG from 3 AECA\u2010negative WG patients, and IgG from healthy donors were tested for their ability to: a) bind to endothelial cells and to display complement\u2010dependent or antibody\u2010dependent cellular cytotoxicity, b) modulate cell membrane expression of adhesion molecules, as evaluated by cytofluorometry and by immunoenzymatic assay, and c) induce the secretion of interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20106, IL\u20108, and monocyte chemotactic protein 1 (MCP\u20101).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. We found that AECA IgG from WG patients do not display any significant cytotoxicity but are able to up\u2010regulate the expression of E\u2010selectin, intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 and to induce the secretion of IL\u20101\u03b2, IL\u20106, IL\u20108, and MCP\u20101.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. AECA in patients with WG could play a potential pathogenetic role by activating endothelial cells, and thus facilitating leukocyte recruitment and adhesion to endothelial surfaces, rather than by displaying a cytotoxic activity.<\/jats:p>","DOI":"10.1002\/art.1780390507","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:40:17Z","timestamp":1171453217000},"page":"758-766","source":"Crossref","is-referenced-by-count":109,"title":["Anti\u2010endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion"],"prefix":"10.1002","volume":"39","author":[{"given":"Nicoletta","family":"del Papa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Guidali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Sironi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tincani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genesio","family":"Balestrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Radice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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