{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:04:59Z","timestamp":1778807099168,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3512,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To determine the involvement of human thioredoxi\/adult T cell leukemia\u2013derived factor (TRX\/ADF) in Sj\u00f6gren's syndrome (SS) and the correlation with Epstein\u2010Barr virus (EBV).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Indirect immunohistochemical techniques and reverse transcriptase polymerase chain reaction were utilized to analyze TRX\/ADF expression and the presence of EBV, using 6 normal tissues and 23 surgical specimens. The kinetics of expression of TRX\/ADF induced by EBV was examined in vitro with peripheral blood B cells from EBV\u2010seronegative donors.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Marked expression of TRX\/ADF was found in the infiltrating B cells and the epithelial cells of salivary gland tissues from patients with SS (11 of 12 cases), but not in those from patients with other salivary gland inflammatory conditions (0 of 11 cases) or those of normal individuals (0 of 6 cases). In immunohistologic analyses, a striking topographic correlation between TRX\/ADF and EBV was found. The coexistence of TRX\/ADF messenger RNA and EBV DNA was detected by polymerase chain reaction (r = 0.75, <jats:italic>P<\/jats:italic> &lt; 0.01). Peripheral blood B cells from EBV\u2010seronegative donors showed de novo synthesis of TRX\/ADF following in vitro infection with EBV. EBV\u2010infected B cell lines all expressed TRX\/ADF. TRX\/ADF was not detected in non\u2010EBV\u2010infected cells. Tumors in SCID mice reconstituted with mononuclear cells of salivary glands from SS patients, which were composed of human B cells carrying EBV DNA, were positive for TRX\/ADF.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. These findings suggest that TRX\/ADF expression closely reflects the intracellular event of EBV reactivation in SS. This is also the first report to show the ectopic in vivo expression of TRX\/ADF in human autoimmune disease.<\/jats:p>","DOI":"10.1002\/art.1780390509","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:40:17Z","timestamp":1171453217000},"page":"773-782","source":"Crossref","is-referenced-by-count":26,"title":["Increased expression of human thioredoxin\/adult T cell leukemia\u2013derived factor in Sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"39","author":[{"given":"Ichiro","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misa","family":"Shimuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Terauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Yodoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231107"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.5.533"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250609"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92384-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.51.3.795-798.1984"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197312202892501"},{"key":"e_1_2_1_9_2","volume-title":"The Herpes Virus","author":"Klein G","year":"1973"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.5.1405"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-1-34"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/356347a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.4049\/jimmunol.137.10.3162","article-title":"Detection of Epstein\u2010Barr virus\u2010associated antigens and DNA in salivary gland biopsies from patients with Sj\u00f6gren's syndrome","volume":"137","author":"Fox RI","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.6.2191"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)80007-9"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310812"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360614"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60836-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1860010123"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.4049\/jimmunol.135.6.3995","article-title":"TCGF (IL2)\u2010receptor inducing factor (s). II. Possible role of ATL\u2010derived factor (ADF) on constitutive IL 2 receptor expression of HTLV\u2010I (+) T cell lines","volume":"135","author":"Okada M","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_21_2","first-page":"578","article-title":"Adult T\u2010cell leukemia\u2010derived factor\/thioredoxin expression on the HTLV\u2010I transformed T\u2010cell lines: heterogenous expression in ATL\u20102 cells","volume":"76","author":"Makino S","year":"1992","journal-title":"Immunology"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.21.8282"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90091-K"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03436.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1128\/jvi.59.3.759-760.1986","article-title":"Nucleotide sequence and protein overproduction of bacteriophage T4 thioredoxin","volume":"59","author":"LeMaster DM","year":"1986","journal-title":"J Virol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9132"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.3.804"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.4049\/jimmunol.140.8.2614","article-title":"IL\u20102 Receptor(p55)\/Tac\u2010inducing factor: purification and characterization of adult T cell leukemia\u2010derived factor","volume":"140","author":"Tagaya Y","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.54.070185.001321"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0889-857X(21)00055-7","article-title":"Criteria for diagnosis of Sj\u00f6gren's syndrome","volume":"20","author":"Fox RI","year":"1994","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76908-9"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(90)90032-U"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.4049\/jimmunol.136.10.3643","article-title":"Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte\u2010dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon\u2010g in rheumatoid arthritis","volume":"136","author":"Lotz M","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.4049\/jimmunol.151.8.4391","article-title":"Cytokine expression after the toropical administration of substance P to human nasal mucosa","volume":"151","author":"Okamoto Y","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90630-0"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1701273"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/iai.13.2.303-310.1976","article-title":"Epstein\u2010Barr virus interactions with human lymphocyte subpopulations: virus adsorption, kinetics of expression of Epstein\u2010Barr virus\u2010associated nuclear antigen, and lymphocyte transformation","volume":"13","author":"Menezes J","year":"1976","journal-title":"Infect Immun"},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0889-857X(21)00847-4","article-title":"Potentiol role of Epstein\u2010Barr virus in Sj\u00f6gren's syndrome","volume":"13","author":"Fox RI","year":"1987","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.1.173.173"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911001)68:7<1583::AID-CNCR2820680720>3.0.CO;2-N"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2118682"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/4.7.811"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.152.11.5532"},{"key":"e_1_2_1_44_2","first-page":"3643","article-title":"Release of lymphokines after infection with Epstein\u2010Barr virus in vitro","volume":"136","author":"Lots M","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91645-O"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780390509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780390509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:59:25Z","timestamp":1700704765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780390509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1002\/art.1780390509"],"URL":"https:\/\/doi.org\/10.1002\/art.1780390509","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}