{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T01:12:47Z","timestamp":1726276367265},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3512,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> Epitopes on Ki antigen were analyzed using synthetic peptides, including KILT, a 16\u2010mer peptide with an amino acid sequence homologous to the SV40 large T antigen nuclear localization signal (SV40 T NLS).<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> In addition to KILT, 4 synthetic peptides, all potential epitopes on Ki antigen according to computer analysis, were prepared and tested for reactivity with 49 anti\u2010Ki\u2013positive lupus sera by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Eighteen sera reacted with KILT, but not with other peptides. The reaction of anti\u2010Ki sera with KILT was specifically inhibited by recombinant Ki antigen. Eight of 49 anti\u2010Ki sera reacted with a 7\u2010mer synthetic peptide of SV40 T NLS, and the reaction was specifically inhibited by KILT.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The 16\u2010mer Ki peptide containing the sequence homologous to the SV40 T NLS is one of the antigenic epitopes recognized by anti\u2010Ki antibodies in lupus sera.<\/jats:p>","DOI":"10.1002\/art.1780390519","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:40:17Z","timestamp":1171453217000},"page":"855-862","source":"Crossref","is-referenced-by-count":4,"title":["An epitope on Ki antigen recognized by autoantibodies from lupus patients shows homology with the sv40 large t antigen nuclear localization 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