{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:23:15Z","timestamp":1767979395446,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3451,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To assess cardiovascular abnormalities in patients with limited systemic sclerosis (SSc), using noninvasive cardiac techniques.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Sixty\u2010three patients with limited SSc were prospectively evaluated with Doppler echocardiography and thallium\u2010201 perfusion scintigraphy after a cold\u2010stress test and radionuclide ventriculography.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. In the patients with limited SSc, there was a significantly high prevalence of abnormal left\u2010 and right\u2010diastolic function parameters (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.0002, respectively), thickening of papillary muscles (46%; <jats:italic>P<\/jats:italic> = 0.003), and mild mitral regurgitation (49%; <jats:italic>P<\/jats:italic> &lt; 0.0001), compared with controls. Systolic pulmonary arterial hypertension was detected in 9 patients (14%), and pericardial effusion in 11 patients (18%). In 64% of patients with limited SSc, an ischemic response was detected on the thallium cold\u2010stress scan; similarly, an ischemic response was detected in 57% of patients with primary Raynaud's phenomenon (<jats:italic>P<\/jats:italic> &lt; 0.0001 versus controls).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Although the frequency of cardiovascular symptoms was low in patients with limited SSc, a significant rate of cardiovascular abnormalities was found by noninvasive cardiac techniques.<\/jats:p>","DOI":"10.1002\/art.1780390710","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:06:32Z","timestamp":1171454792000},"page":"1138-1145","source":"Crossref","is-referenced-by-count":71,"title":["Comprehensive noninvasive assessment of cardiac involvement in limited systemic sclerosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Jaume","family":"Candell\u2010Riera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Armadans\u2010Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen\u2010Pilar","family":"Sime\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Castell\u2010Conesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicent","family":"Fonollosa\u2010Pla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herminio","family":"Garc\u00eda\u2010Del\u2010Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Vaqu\u00e9\u2010Rafart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel","family":"Vilardell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Soler\u2010Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90207-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(89)90032-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.23.3.243"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(66)90246-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90008-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.3.483"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90478-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90351-2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00214.x"},{"key":"e_1_2_1_11_2","first-page":"343","article-title":"Two\u2010dimensional echocardiographic measurements in systemic sclerosis and a matched reference population","volume":"5","author":"Kazzam F","year":"1991","journal-title":"Am J Noninvas Cardiol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351117"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)92690-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90694-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90711-4"},{"key":"e_1_2_1_16_2","first-page":"68","article-title":"Left ventricular diastolic function in systemic sclerosis: assessment by radionuclide angiography","volume":"32","author":"Pace L","year":"1992","journal-title":"J Nucl Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198401193100302"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90110-4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-5-661"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.9.718"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605293142201"},{"key":"e_1_2_1_22_2","first-page":"1395","article-title":"Nicardipine improves myocardial perfusion in systemic sclerosis","volume":"15","author":"Kahan A","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92088-6"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340211"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_26_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_1_27_2","first-page":"485","article-title":"Raynaud's phenomenon: a proposal for classification","volume":"10","author":"LeRoy EC","year":"1992","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.4.613"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.3.506"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062470"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.175"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/oxfordjournals.eurheartj.a059638","article-title":"Diagnostic accuracy of radionuclide techniques in patients with equivocal electrocardiographic exercise testing","volume":"11","author":"Candell\u2010Riera J","year":"1990","journal-title":"Eur Heart J"},{"key":"e_1_2_1_33_2","volume-title":"Applied regression analysis and other multivariable methods","author":"Kleimbaum DG","year":"1988"},{"key":"e_1_2_1_34_2","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","journal-title":"Scand J Statist"},{"key":"e_1_2_1_35_2","volume-title":"Statistical Package for Epidemiology and Clinical Trials","author":"Epilog Plus","year":"1990"},{"issue":"1","key":"e_1_2_1_36_2","first-page":"59","article-title":"Systemic sclerosis: subsets according to analysis of survival and disability prognostic factors (abstract)","volume":"33","author":"Sime\u00f3n CP","year":"1994","journal-title":"Br J Rheumatol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780390710","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780390710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:36:53Z","timestamp":1700703413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780390710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1002\/art.1780390710"],"URL":"https:\/\/doi.org\/10.1002\/art.1780390710","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}