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Using a standardized questionnaire, 271 consecutive adults, primarily black, with possible or proven <jats:italic>Chlamydia trachomatis<\/jats:italic> genital infection were screened for symptoms of ReA. A followup questionnaire was administered 6 weeks later by mail. Patients who reported at least 1 symptom were evaluated by a rheumatologist. HLA\u2013B typing was performed on patients with objective ReA features.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Nine of 217 patients (4.1%) with genital infection\/inflammation had objective ReA features. Chlamydial or nongonococcal STD syndromes were diagnosed in 8 of these 9 patients (88%). Genital infection\/inflammation was asymptomatic in 78% of patients with ReA features. HLA\u2013B27 or other B7\u2013cross\u2010reactive group antigens were not associated with the occurrence of ReA.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Nongonococcal genital infections, often asymptomatic, can trigger a relatively mild ReA in a larger number of exposed patients than previously thought, irrespective of the individual's HLA status.<\/jats:p>","DOI":"10.1002\/art.1780390715","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:06:32Z","timestamp":1171454792000},"page":"1172-1177","source":"Crossref","is-referenced-by-count":52,"title":["Reactive arthritis in patients attending an urban sexually transmitted diseases clinic"],"prefix":"10.1002","volume":"39","author":[{"given":"Eric","family":"Rich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Edward W.","family":"Hook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela S.","family":"Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry 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