{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:25:44Z","timestamp":1782552344707,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3420,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To examine trends in the incidence and prevalence of juvenile rheumatoid arthritis (JRA) in Rochester, Minnesota, over 33 years.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. The diagnostic retrieval system of the Rochester Epidemiology Project was utilized to screen medical records of all Rochester residents with any potential diagnoses of JRA from 1978 to 1993 (based on the American College of Rheumatology 1977 revised criteria). In addition, all cases of JRA from our previously identified cohort from 1960\u20131979 were verified, and the 2 data sets were combined, resulting in an incidence cohort spanning 33 years (1960\u20131993).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Of the 1,240 medical records screened, we identified 65 cases of JRA diagnosed between 1960 and 1993 (48 females, 17 males). The average followup for cases was 12.7 years (range 0\u201334 years) for a total of 833 person\u2010years of observation. A bimodal distribution of age at diagnosis was observed, with peaks between 0 and 4 years and 9 and 15 years. Seventy\u2010two percent of patients had pauciarticular\u2010onset, 17% had polyarticular\u2010onset, and 11% had systemic\u2010onset disease. Progression of pauciarticular to polyarticular disease occurred in 11% of the cases. The overall age\u2010 and sex\u2010adjusted incidence rate was 11.7 per 100,000 population (95% confidence intervals 8.7, 14.8). The incidence rate per 100,000 population was 15.0, 14.1, and 7.8 for the time periods 1960\u20131969, 1970\u20131979, and 1980\u20131993, respectively (<jats:italic>P<\/jats:italic> = 0.024). A 3\u2010year, centered, moving average, which was used to display time trends in incidence, suggested a cyclical pattern, with incidence peaks in 1967, 1975, and 1987.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. An overall decrease in the incidence rate over the last decade was observed, most marked in the pauciarticular\u2010 and systemic\u2010onset subtypes. This decrease, along with the observed cyclical pattern, suggest that environmental factors may influence disease frequency.<\/jats:p>","DOI":"10.1002\/art.1780390817","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:02:15Z","timestamp":1171454535000},"page":"1385-1390","source":"Crossref","is-referenced-by-count":106,"title":["Juvenile rheumatoid arthritis in rochester, minnesota 1960\u20131993. Is the epidemiology changing?"],"prefix":"10.1002","volume":"39","author":[{"given":"Lynne S.","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey M.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"O'Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine E.","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_3_2","first-page":"745","article-title":"Epidemiology of juvenile rheumatoid arthritis in Manitoba, Canada, 1975\u201392: cycles in incidence","volume":"22","author":"Oen K","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1542\/peds.90.6.950","article-title":"Epidemiology of juvenile chronic arthritis in southwestern Sweden: a 5\u2010year prospective population study","volume":"90","author":"Gare BA","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.73.10.1202"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260504"},{"key":"e_1_2_1_7_2","first-page":"217","article-title":"Epidemiologic survey of juvenile chronic arthritis in France: comparison of data obtained from two different regions","volume":"5","author":"Prieur AM","year":"1987","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_8_2","first-page":"162","article-title":"Juvenile arthritis in various racial groups in British Columbia","volume":"20","author":"Hill R","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","first-page":"161","article-title":"Rheumatic diseases in Hawaii","volume":"20","author":"Hicks RM","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780180309"},{"key":"e_1_2_1_11_2","first-page":"S1","article-title":"A prognostic study of juvenile rheumatoid arthritis","volume":"166","author":"Laaksonen AL","year":"1966","journal-title":"Acta Pediatr Scand"},{"key":"e_1_2_1_12_2","series-title":"USDHEW Publication #(NIH)76\u2010877","volume-title":"Chronic Childhood Illness: An Assessment of Outcome","author":"Froom J","year":"1976"},{"key":"e_1_2_1_13_2","series-title":"National Health Survey, Series 10, No. 92","volume-title":"Prevalence of Chronic Skin and Musculoskeletal Conditions, United States, 1969","author":"Wilder MH","year":"1974"},{"key":"e_1_2_1_14_2","series-title":"National Health Survey, Series 10, No. 124","volume-title":"Prevalence of Chronic Skin and Musculoskeletal Conditions, United States, 1976","author":"Bonham GS","year":"1978"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261006"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1081-54"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3244-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291008"},{"key":"e_1_2_1_20_2","volume-title":"Population Studies of the Rheumatic Diseases","author":"Bywaters EGL","year":"1968"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300719"},{"issue":"9","key":"e_1_2_1_22_2","first-page":"S60","article-title":"Is there a seasonal onset to systemic onset juvenile rheumatoid arthritis (abstract)?","volume":"36","author":"Feldman B","year":"1993","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.1.2"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)93136-0"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510313131803"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(78)90032-X"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.3.176"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(86)90038-7"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.235.23.2496"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-3-199508010-00006"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.2307\/3350087"}],"container-title":["Arthritis &amp; 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