{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:39:49Z","timestamp":1791293989324,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3389,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To examine interrelationships among myositis subsets, autoantibodies, and major histocompatibility complex (MHC) class II alleles across ethnic lines, and to localize genetic susceptibility (presence of HLA\u2013DR versus DQ) to myositis within the MHC class II region.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. MHC class II alleles (HLA\u2013<jats:italic>DRB1, DQA1<\/jats:italic>, and <jats:italic>DQB1<\/jats:italic>, detected by DNA oligotyping) and myositis\u2010specific autoantibodies (MSA) were determined in 224 patients with various myositis syndromes, including 89 whites, 89 African\u2010Americans, 25 Mexican\u2010Americans, and 21 Japanese.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Anti\u2013Jo\u20101 (histidyl\u2013transfer RNA [tRNA] synthetase) and other MSAs (anti\u2013PL\u201012, anti\u2013PL\u20107, anti\u2010OJ, anti\u2010EJ, anti\u2010KJ, anti\u2010tRNA, and anti\u2013signal recognition particle) were equally distributed among the races, but occurred more often in patients with polymyositis (PM) than in those with dermatomyositis (DM) or other myositis syndromes. MSA frequencies were significantly positively associated with anti\u2013Ro (SS\u2010A) (<jats:italic>P<\/jats:italic> = 0.002), and significantly negatively associated with anti\u2013U1 RNP (<jats:italic>P<\/jats:italic> = 0.003). Frequencies of the HLA\u2013<jats:italic>DRB1*0301<\/jats:italic> (DR3), <jats:italic>DQA1*0501<\/jats:italic>, and <jats:italic>DQB1*0201<\/jats:italic> (DQ2) alleles (and haplotype) were each increased in white patients with myositis, especially those with PM, but most strikingly in those with MSAs. However, in the other ethnic groups, except the Japanese group, only frequencies of HLA\u2013<jats:italic>DQA1*0501<\/jats:italic> and the structurally similar <jats:italic>DQA1*0401<\/jats:italic> alleles were significantly increased. The presence of HLA\u2013<jats:italic>DQA1*0501<\/jats:italic> or *<jats:italic>0401<\/jats:italic> was most significantly associated with anti\u2013Jo\u20101, anti\u2013PL\u201012, and other MSAs, compared with myositis patients without MSAs (<jats:italic>P<\/jats:italic> = 0.0008, <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 0.01, odds ratio [OR] = 3.7), and with normal, ethnically matched controls (<jats:italic>P<\/jats:italic> = 3 \u00d7 10<jats:sup>\u22127<\/jats:sup>, <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> = 1 \u00d7 10<jats:sup>\u22126<\/jats:sup>, OR = 6.5). Among MSA\u2010positive patients who were negative for HLA\u2013<jats:italic>DQA1*0501<\/jats:italic> and *<jats:italic>0401<\/jats:italic>, including Japanese patients, the HLA\u2013<jats:italic>DQA1*0101<\/jats:italic> and *<jats:italic>0103<\/jats:italic> alleles predominated. In addition, there appeared to be a negative association of the HLA\u2013DR2 alleles (<jats:italic>DRB1*1501<\/jats:italic> and *<jats:italic>1503<\/jats:italic>) with PM (<jats:italic>P<\/jats:italic> = 0.007, <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> not significant, OR = 0.39), but not with DM or myositis overall.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. By transracial gene mapping, genetic susceptibility to anti\u2013Jo\u20101 and other MSAs in patients with myositis can be localized within the MHC region to the HLA\u2013<jats:italic>DQA1<\/jats:italic> locus.<\/jats:p>","DOI":"10.1002\/art.1780390910","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:01:54Z","timestamp":1171454514000},"page":"1507-1518","source":"Crossref","is-referenced-by-count":150,"title":["Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis"],"prefix":"10.1002","volume":"39","author":[{"given":"Frank C.","family":"Arnett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira 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