{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:26:06Z","timestamp":1790267166493,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3389,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the combined effect of systemic corticosteroid and antibiotic therapy on the course of septic arthritis.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. The murine model of hematogenously acquired <jats:italic>Staphylococcus aureus<\/jats:italic> arthritis was used. Mice were treated with corticosteroids and antibiotics, and were followed up individually. Arthritis was evaluated clinically and histopathologically. Serum samples and bacterial isolates were also analyzed.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. The prevalence of arthritis 14 days after the onset of the disease was 22% in the corticosteroid and antibiotic\u2013treated group, as compared with 81% in the control (nontreated) group and 48% in the antibiotic\u2010treated group. The severity of arthritis also decreased in the corticosteroid and antibiotic\u2010treated group, as did the mortality rate. Immunohistochemical analysis revealed a dramatic decrease in T cells and macrophages in the synovium of mice that took the combined therapy. The mechanisms leading to this outcome include the inhibitory effect of corticosteroids on T cell and B cell proliferation and differentiation, such as suppression of interferon\u2010\u03b3 (IFN\u03b3) production. Serum levels of IFN\u03b3 were decreased 4\u2010fold in the antibiotic\u2010treated group compared with the controls; a 15\u2010fold decrease was observed in the corticosteroid and antibiotic\u2013treated animals. In addition, serum NO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> was significantly decreased in mice treated with antibiotics (<jats:italic>P<\/jats:italic> \u2264 0.05), as well as in mice treated with corticosteroids and antibiotics (<jats:italic>P<\/jats:italic> \u2264 0.001).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Systemic corticosteroid administration along with antibiotic therapy had beneficial effects on the course and outcome of <jats:italic>S aureus<\/jats:italic> arthritis.<\/jats:p>","DOI":"10.1002\/art.1780390921","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:01:54Z","timestamp":1171454514000},"page":"1596-1605","source":"Crossref","is-referenced-by-count":86,"title":["Addition of corticosteroids to antibiotic treatment ameliorates the course of experimental <i>Staphylococcus aureus<\/i> 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