{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:38:18Z","timestamp":1790602698495,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3328,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To determine whether T lymphocyte reactivity to endogenous human hsp60 plays a regulatory role in the course of oligoarticular juvenile rheumatoid arthritis (JRA).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. A prospective, longitudinal study of T cell reactivity to HSP in 15 patients with newly diagnosed HLA\u2010B27 negative oligoarticular JRA was performed. Results were compared with those in a group of 20 patients with newly diagnosed polyarticular or systemic JRA or with acute arthritis caused by other systemic diseases or viral infections, as well as with those in a group of 9 healthy control subjects.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. In 86% of the patients with oligoarticular JRA (13 of 15), significant T lymphocyte proliferative responses to hsp60 were found in peripheral blood mononuclear cells and\/or synovial fluid mononuclear cells within 3 months after the onset of arthritis. Only 5% of the patients in the rheumatologic disease control group (1 of 20) showed such positivity. All patients with oligoarticular JRA and positive responses to human hsp60 developed a remission of their disease within 12 weeks. During this period of remission, blood samples were taken from 8 patients and showed significantly lower and even negative responses to hsp60, compared with active disease, when all 8 patients had good responses.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. The results show that significant proliferative responses to human hsp60 can be found early in the course of oligoarticular JRA. Furthermore, these responses correlate with disease activity in such a manner that T cell reactivity to human hsp60 seems to be associated with disease remission.<\/jats:p>","DOI":"10.1002\/art.1780391108","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:48:53Z","timestamp":1171453733000},"page":"1826-1832","source":"Crossref","is-referenced-by-count":95,"title":["Autoreactivity to human heat\u2010shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"39","author":[{"given":"A. B. J.","family":"Prakken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"van Eden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. T.","family":"Rijkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Toebes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. R.","family":"de Graeff\u2010Meeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J. M.","family":"Zegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0593-56"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.22.120188.003215"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/jvi.44.2.703-707.1982","article-title":"Newcastle virus stimulates the cellular accumulation of stress (heat shock) mRNAs and proteins","volume":"44","author":"Collins PL","year":"1982","journal-title":"J Virol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.2279"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.12.4267"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.003031"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90093-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749509100918"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83134-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.449"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/331171a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.6.1805"},{"key":"e_1_2_1_14_2","first-page":"1013","article-title":"Antibodies to the mycobacterial 65 kDa heat shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis","volume":"137","author":"De Graeff\u2010Meeder ER","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93057-G"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117801"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.3.943"},{"key":"e_1_2_1_18_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90003-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4049\/jimmunol.151.4.2273","article-title":"T cell epitope expression of mycobacterial and homologous human 65\u2010kilodalton heat shock protein peptides in short term cell lines from patients with Beh\u00e7et's disease","volume":"151","author":"Pervin K","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-91-22179"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/4.7.719"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/2241322a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6336851"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74594-2_3"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.4049\/jimmunol.152.7.3656","article-title":"Differential mycobacterial 65\u2010kDa heat shock protein T cell epitope recognition after adjuvant arthritis\u2010inducing or protective immunization protocols","volume":"152","author":"Anderton SM","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.005015"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780391108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780391108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T20:06:37Z","timestamp":1700769997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780391108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1002\/art.1780391108"],"URL":"https:\/\/doi.org\/10.1002\/art.1780391108","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}