{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:47:47Z","timestamp":1767016067816},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3328,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To analyze the levels of free carnitine and carnitine esters in the muscles of patients with inflammatory myopathies.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Six men and 7 women with inflammatory myopathy and 25 age\u2010matched healthy controls were studied. Free carnitine and carnitine esters in muscle homogenates were measured by a radiochemical procedure. Muscle histochemical staining and measurement of respiratory chain enzyme activity were also performed.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Eleven patients had muscle carnitine insufficiency. Five of them had subsarcolemmal oxidative accumulations, 5 had lipid droplets, and 4 had defects of the respiratory chain enzyme complexes.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Abnormal distribution of muscle carnitine is present in patients with inflammatory myopathies and could impair muscle function. Coexistent mitochondrial dysfunction may contribute to carnitine insufficiency.<\/jats:p>","DOI":"10.1002\/art.1780391113","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:48:53Z","timestamp":1171453733000},"page":"1869-1874","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal carnitine distribution in the muscles of patients with idiopathic inflammatory myopathy"],"prefix":"10.1002","volume":"39","author":[{"given":"Joaquin","family":"Arenas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Gonzalez\u2010Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Gomez\u2010Reino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252107"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.001401"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90414-Z"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198412000-00021"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160205"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80246-7"},{"key":"e_1_2_1_8_2","first-page":"773","article-title":"The effect of L\u2010carnitine on the AZT\u2010induced destruction of human myotubes. 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