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In the 11 previously reported cases, corticosteroid treatment, which has been widely used, was shown to have an unpredictable effect on the evolution of FR. We report a case of FR that was treated with methotrexate for 5 years, which led to complete recovery. This drug may be considered an effective treatment for FR. Further cases are needed to confirm this preliminary experience.<\/jats:p>","DOI":"10.1002\/art.1780391218","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T11:48:28Z","timestamp":1171453708000},"page":"2070-2073","source":"Crossref","is-referenced-by-count":22,"title":["Preliminary experience with low\u2010dose methotrexate in fibroblastic rheumatism"],"prefix":"10.1002","volume":"39","author":[{"given":"Olivier","family":"Vittecoq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Othmane","family":"Mejjad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Joly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Thomine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Lauret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Michel","family":"Thomine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier Le","family":"Lo\u00ebt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"345","article-title":"Une nouvelle entit\u00e9: le rhumatisme fibroblastique","volume":"47","author":"Chaouat Y","year":"1980","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_1_3_2","first-page":"469","article-title":"Rhumatisme fibroblastique: un cas avec \u00e9tude de l'histologie synoviale","volume":"49","author":"Crouzet J","year":"1982","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)80186-4"},{"key":"e_1_2_1_5_2","first-page":"463","article-title":"Le rhumatisme fibroblastique du sujet \u00e2g\u00e9: donn\u00e9es histopathologiques, ultrastructurales et probl\u00e8mes de diagnostic diff\u00e9rentiel","volume":"54","author":"Taccari E","year":"1987","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_1_6_2","first-page":"199","article-title":"Rhumatisme fibroblastique","volume":"117","author":"Levigne V","year":"1990","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_1_7_2","first-page":"828","article-title":"Le rhumatisme fibroblastique","volume":"117","author":"Barbaud A","year":"1990","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00366771"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb15151.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01185.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1001\/archderm.1980.01640350073020","article-title":"Nodular scleroderma and pleomorphic acid\u2010fast bacteria","volume":"116","author":"Cantwell AR","year":"1980","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199312000-00014"},{"key":"e_1_2_1_13_2","first-page":"1763","article-title":"Low dose methotrexate in systemic sclerosis","volume":"18","author":"Van den Hoogen FH","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_14_2","first-page":"627","article-title":"Methotrexate treatment of multicentric reticulohistiocytosis","volume":"18","author":"Gourmelen O","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_1_15_2","first-page":"238","article-title":"Methotrexate inhibits proliferation but not interleukin 1 stimulated secretory activities of cultured human synovial fibroblasts","volume":"20","author":"Meyer FA","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340205"}],"container-title":["Arthritis &amp; 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