{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:13:46Z","timestamp":1762251226823},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3267,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the potential of a monoclonal proteinase 3\u2010antineutrophil cytoplasmic antibody (PR3\u2010ANCA) antiidiotype autoantibody (5\/7 anti\u2010Id) as a candidate for specific immunotherapy in Wegener's granulomatosis (WG), and to estimate the immuno\u2010diagnostic value of the corresponding idiotype (5\/7 Id).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. We analyzed the incidence of 5\/7 Id in patients with ANCA\u2010associated vasculitides (WG, microscopic polyangiitis, Churg\u2010Strauss syndrome), in disease controls (systemic lupus erythematosus patients), and in healthy donors. We then investigated the presence of 5\/7 Id in relation to disease stage, clinical activity, and organ manifestations in 86 patients with WG. Finally, we investigated the ability of the 5\/7 anti\u2010Id reagent to inhibit the binding of PR3\u2010ANCA to corresponding antigen in 19 WG patients.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. The incidence of 5\/7 Id was significantly more frequent in WG patients (43 of 86; 50%). We did not find a significant correlation between the prevalence of idiotype expression and disease activity or organ manifestations. Further, we demonstrated in vitro suppression of PR3\u2010ANCA antigen binding activity by 5\/7 anti\u2010Id in 11 of 19 WG patients who were positive for 5\/7 Id.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. This study shows that 5\/7 Id is a common idiotype with a significantly increased incidence in WG and that 5\/7 anti\u2010Id inhibits PR3\u2010ANCA antigen binding activity. Based on these observations, we conclude that 5\/7 anti\u2010Id is a promising tool for the development of a specific immunotherapy for WG.<\/jats:p>","DOI":"10.1002\/art.1780400118","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:15:56Z","timestamp":1171455356000},"page":"135-142","source":"Crossref","is-referenced-by-count":14,"title":["Incidence and disease associations of a proteinase 3\u2212antineutrophil cytoplasmic antibody idiotype (5\/7 Id) whose antiidiotype inhibits proteinase 3\u2212antineutrophil cytoplasmic antibody antigen binding activity"],"prefix":"10.1002","volume":"40","author":[{"given":"Hendryk P.","family":"Strunz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Csernok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang 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