{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:42Z","timestamp":1787237862201,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To investigate possible mechanisms of growth impairment in children with juvenile rheumatoid arthritis (JRA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    . Eighteen prepubertal children with JRA and growth retardation received recombinant human growth hormone (rHuGH) for 1 year. Growth hormone profiles over 24 hours were obtained before treatment in 12 patients; the levels did not differ from those in \u201cshort normal\u201d children. Levels of insulin\u2010like growth factor 1 (IGF\u20101), IGF binding proteins (IGFBPs) 1 and 3, insulin, osteocalcin, and C\u2010reactive protein (CRP), as well as the erythrocyte sedimentation rate were measured serially. Pretreatment levels were compared with control levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    . In JRA patients, IGF\u20101, IGFBP\u20103, and osteocalcin levels were significantly lower and insulin levels significantly higher than those in controls, but there was no significant difference in the level of IGFBP\u20101. With rHuGH treatment, height velocity and mean levels of IGF\u20101, osteocalcin, and insulin increased significantly, while mean levels of IGFBP\u20101 fell significantly. Levels of IGFBP\u20103 correlated with those of IGF\u20101. The height velocity correlated positively with IGF\u20101 and osteocalcin, and negatively with IGFBP\u20101. Levels of IGFBP\u20101 were inversely related to those of insulin and IGF\u20101. There was a significant negative correlation between the CRP and height velocity, IGF\u20101 level, and osteocalcin level.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . IGF\u20101 production is impaired in children with active JRA. Treatment with a therapeutic dose of rHuGH can rectify the IGF\u20101 deficiency within 4 days, but its effect is adversely influenced by the acute\u2010phase response, as reflected by an elevated CRP level.\n                  <\/jats:p>","DOI":"10.1002\/art.1780400218","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T07:24:20Z","timestamp":1171437860000},"page":"332-340","source":"Crossref","is-referenced-by-count":63,"title":["Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin\u2010like growth factor 1, insulin\u2010like growth factor binding proteins 1 and 3, and osteocalcin"],"prefix":"10.1002","volume":"40","author":[{"given":"Ursula M.","family":"Davies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Reeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Camacho\u2010Hubner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Charlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M.","family":"Ansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Preece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M. M.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"153","article-title":"Treatment of growth retardation in juvenile chronic arthritis with recombinant human growth hormone","volume":"21","author":"Davies UM","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.15.4.295"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200509"},{"key":"e_1_2_1_5_2","first-page":"176","article-title":"Alternate\u2010day corticosteroid therapy in juvenile chronic polyarthritis","volume":"1","author":"Ansell BM","year":"1974","journal-title":"J Rheumatol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7079756"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.935"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb17983.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-3-432"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.4.2234"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1986.tb03596.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.6.665"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-2-273"},{"key":"e_1_2_1_14_2","first-page":"53","article-title":"Growth hormone studies in patients with rheumatoid arthritis with or without glucocorticoid therapy","volume":"118","author":"Butenandt O","year":"1974","journal-title":"Eur J Pediatr"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5722.547"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.9.602"},{"key":"e_1_2_1_17_2","first-page":"655","article-title":"Insulin\u2010like growth factors I and II in children with systemic onset juvenile arthritis","volume":"15","author":"Bennett AE","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_1_18_2","first-page":"557","article-title":"Serum IGF\u2010I levels and growth failure in juvenile chronic arthritis","volume":"7","author":"Aitman TJ","year":"1989","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-4-618"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81605-1"},{"key":"e_1_2_1_21_2","first-page":"1189","article-title":"Biochemical prediction of changes in spinal bone mass in juvenile chronic (or rheumatoid) arthritis treated with glucocorticoids","volume":"20","author":"Reeve J","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331005"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441894"},{"key":"e_1_2_1_24_2","first-page":"107","article-title":"Treatment of growth failure with human growth hormone in patients with juvenile chronic arthritis: a pilot study","volume":"37","author":"Svantesson H","year":"1991","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1250311"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0020201"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1070563"},{"key":"e_1_2_1_28_2","first-page":"428","article-title":"Randomized, double\u2010blind trial of deflazacort versus prednisolone in juvenile chronic arthritis","volume":"88","author":"Loftus J","year":"1991","journal-title":"Pediatrics"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.41.11.1203"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb12039.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80696-3"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198510000-00001"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-53-6-1247"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1991.tb03495.x"},{"key":"e_1_2_1_35_2","first-page":"655","article-title":"Nutritional status and growth in juvenile rheumatoid arthritis","volume":"15","author":"Bacon MC","year":"1988","journal-title":"Semin Arthritis Rheum"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400350123019"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb02377.x"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02921.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb00859.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-6-2693"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1632"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-5-1292"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-3-582"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-1-122"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90008-7"},{"key":"e_1_2_1_46_2","first-page":"105","article-title":"The effects of high\u2010dose glucocorticoid administration on serum BGP, serum osteocalcin and vitamin D metabolites in normal subjects","volume":"4","author":"Nielsen HK","year":"1988","journal-title":"Bone"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(90)90214-S"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1250067"},{"key":"e_1_2_1_49_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1651-2227.1988.tb10794.x","article-title":"Actions of growth hormone\u2014current views","volume":"343","author":"Isaksson OGP","year":"1988","journal-title":"Acta Paediatr Scand"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-1-44"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(84)90064-X"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100605"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340912"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.5.454"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/306378a0"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780311206"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06368.x"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780400218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780400218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T15:47:40Z","timestamp":1700754460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780400218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1002\/art.1780400218"],"URL":"https:\/\/doi.org\/10.1002\/art.1780400218","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}