{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:49:24Z","timestamp":1791679764879,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1997,2]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:italic>\n . To develop and validate the Vasculitis Damage Index (VDI) for the standardized clinical assessment of damage in the systemic vasculitides.\n <\/jats:p>\n \n Methods<\/jats:italic>\n . Using a nominal group consensus approach, the Birmingham Vasculitis Group generated guiding principles for assessment of damage in all systemic vasculitides. Damage was defined as irreversible change resulting from scars. Consensus principles were developed into the VDI, including guidelines for use, a list of items of damage, and a glossary.\n <\/jats:p>\n \n Results<\/jats:italic>\n . For 100 surviving patients with systemic vasculitis, the median VDI score at last observation was 3 (range 0\u20138). Within the Wegener's granulomatosis subgroup, the median VDI score for 12 non\u2010survivors was higher than for 47 survivors (non\u2010survivors median score 7, interquartile range 5\u20138 versus survivors median score 4, interquartile range 2\u20135;\n P<\/jats:italic>\n = 0.003). VDI scores for 100 patients with systemic vasculitis increased from initial presentation to last observation by a median score of 3 (range 1\u20134;\n P<\/jats:italic>\n < 0.001). The VDI assesses more items and is more sensitive to change than other indices of damage (\n P<\/jats:italic>\n < 0.001). Using the VDI, trained observers can produce moderately consistent damage scores.\n <\/jats:p>\n \n Conclusion<\/jats:italic>\n . The VDI is a sensitive, reproducible, comprehensive, and credible clinical tool for quantifying damage. The data presented herein should enable further validation and testing of the VDI in specific vasculitic syndromes, and should facilitate the comparison of different therapies.\n <\/jats:p>","DOI":"10.1002\/art.1780400222","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T07:24:20Z","timestamp":1171437860000},"page":"371-380","source":"Crossref","is-referenced-by-count":523,"title":["Development and initial validation of the vasculitis damage index for the standardized clinical assessment of damage in the systemic vasculitides"],"prefix":"10.1002","volume":"40","author":[{"given":"A. R.","family":"Exley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Luqmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. D.","family":"Kitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. O. S.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Adu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"533","article-title":"Wegener's granulomatosis: pathology and review of the literature","volume":"58","author":"Godman GC","year":"1954","journal-title":"Arch Pathol"},{"key":"e_1_2_1_3_2","first-page":"26","article-title":"Polyarteritis nodosa","volume":"26","author":"Rose GA","year":"1957","journal-title":"QJM"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197104292841703"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-1-76"},{"key":"e_1_2_1_6_2","first-page":"779","article-title":"Relapses in patients with a systemic vasculitis","volume":"86","author":"Gordon M","year":"1993","journal-title":"QJM"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-488"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370403"},{"key":"e_1_2_1_9_2","first-page":"671","article-title":"Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis","volume":"87","author":"Luqmani RA","year":"1994","journal-title":"QJM"},{"issue":"9","key":"e_1_2_1_10_2","first-page":"S209","article-title":"The SLICC\/ACR Damage Index for SLE (abstract)","volume":"35","author":"Gladman D","year":"1992","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6840.1491"},{"key":"e_1_2_1_13_2","first-page":"275","article-title":"Vital assessment of vasculitis","volume":"13","author":"Bacon PA","year":"1995","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"e_1_2_1_14_2","first-page":"S340","article-title":"The Vasculitis Damage Index (abstract)","volume":"38","author":"Exley A","year":"1995","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330802"},{"key":"e_1_2_1_16_2","first-page":"161","article-title":"Classical vs non\u2010renal Wegener's granulomatosis","volume":"87","author":"Luqmani RA","year":"1994","journal-title":"QJM"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.2.115"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371214"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"e_1_2_1_20_2","first-page":"1611","article-title":"What is the best source of useful data on the treatment of rheumatoid arthritis: clinical trials, clinical observations, or clinical protocols?","volume":"22","author":"Pincus T","year":"1995","journal-title":"J Rheumatol"},{"issue":"9","key":"e_1_2_1_21_2","first-page":"S340","article-title":"Functional assessment in vasculitis using the SF\u201036 (abstract)","volume":"38","author":"Exley A","year":"1995","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780400222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780400222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T15:46:36Z","timestamp":1700754396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780400222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1002\/art.1780400222"],"URL":"https:\/\/doi.org\/10.1002\/art.1780400222","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}