{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:17:42Z","timestamp":1785521862232,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3147,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To determine if minocycline is an effective therapy for seropositive rheumatoid arthritis (RA) when used within the first year of disease.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> The Rheumatoid Arthritis Investigational Network enrolled 46 patients with RA of &lt;1 year duration into a 6\u2010month study of minocycline (100 mg twice daily) versus placebo. All patients were rheumatoid factor positive. The primary end point of the study was successful completion of 6 months of treatment with no drug toxicity while maintaining 50% improvement in composite symptoms of arthritis.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Eighteen of the 46 patients who were enrolled met 50% improvement criteria at 3 months, and maintained at least a 50% improvement for 6 months with no significant drug toxicity. Among them were 15 of the 23 patients (65%) treated with minocycline and 3 of 23 patients (13%) treated with placebo (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> In patients with early seropositive RA, therapy with minocycline is superior to placebo.<\/jats:p>","DOI":"10.1002\/art.1780400510","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:45:20Z","timestamp":1171457120000},"page":"842-848","source":"Crossref","is-referenced-by-count":147,"title":["Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"40","author":[{"given":"James R.","family":"O'Dell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Haire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Drymalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Wees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Blakely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin","family":"Churchill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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