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The abnormalities found were consistent with those associated with maternal ingestion of MTX at dosage levels used to induce abortions, i.e., the group of abnormalities referred to as the \u201caminopterin syndrome.\u201d Although weekly low\u2010dose MTX has been associated with spontaneous abortions, this is, to our knowledge, the first case report describing multiple congenital abnormalities consistent with MTX embryopathy secondary to weekly low\u2010dose MTX treatment.<\/jats:p>","DOI":"10.1002\/art.1780400527","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:45:20Z","timestamp":1171457120000},"page":"971-973","source":"Crossref","is-referenced-by-count":122,"title":["Multiple congenital anomalies associated with weekly low\u2010dose methotrexate treatment of the mother"],"prefix":"10.1002","volume":"40","author":[{"given":"Lenore M.","family":"Buckley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Bullaboy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Leichtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Marquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00778.x"},{"key":"e_1_2_1_3_2","first-page":"321","article-title":"Folate deficiency in vitro pathogenesis. 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