{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:22:02Z","timestamp":1792707722030,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3116,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To determine the expression of interleukin\u20106 (IL\u20106), IL\u201011, leukemia inhibitory factor (LIF), and oncostatin M (OSM) and their major cellular sources in the joints of rheumatoid arthritis (RA) patients, as well as the correlation of circulating levels of these IL\u20106\u2010type cytokines and C\u2010reactive protein (CRP).<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Messenger RNA (mRNA) and protein levels for IL\u20106, IL\u201011, LIF, and OSM were determined by using reverse transcription\u2010polymerase chain reaction and enzyme\u2010linked immunosorbent assay, respectively.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Cells isolated from the synovium of RA patients expressed mRNA for IL\u20106, IL\u201011, LIF, and OSM at higher levels than did synovial cells from osteoarthritis (OA) patients, and spontaneously released greater quantities of these proteins in culture. Fibroblast cell lines derived from RA synovium were able to produce IL\u20106, IL\u201011, and LIF, but not OSM, when stimulated with IL\u20101 and tumor necrosis factor \u03b1. OSM was found to be produced spontaneously by synovial tissue macrophages. IL\u20106, IL\u201011, LIF, and OSM were present in synovial fluid from the RA patients; levels of IL\u20106, LIF, and OSM were present in significantly greater quantities in RA patients than in OA patients. However, only IL\u20106 was significantly elevated in the serum of RA patients and correlated with the serum CRP level, while other IL\u20106\u2010type cytokines were not detected.<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> IL\u20106, IL\u201011, LIF, and OSM are all produced in large amounts at the site of disease activity, but IL\u20106 derived from synovial fibroblasts may be the major hormone\u2010like mediator that induces the hepatic synthesis of acute\u2010phase proteins in RA.<\/jats:p>","DOI":"10.1002\/art.1780400614","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:42:54Z","timestamp":1171456974000},"page":"1096-1105","source":"Crossref","is-referenced-by-count":186,"title":["The synovial expression and serum levels of interleukin\u20106, interleukin\u201011, leukemia inhibitory factor, and oncostatin m in rheumatoid 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