{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:02:31Z","timestamp":1791140551856,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3055,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate interleukin\u201010 (IL\u201010) production in relatives of patients with systemic lupus erythematosus (SLE).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Production of IL\u201010 was evaluated in 13 families in which several members had SLE. The constitutive IL\u201010 production in SLE patients (n = 16) was compared with that in healthy members of these multiplex families (n = 70), in 30 SLE patients who had no relatives with SLE, and in 46 healthy unrelated controls.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. The level of IL\u201010 production did not differ between SLE patients who were members and those who were not members of multiplex families (mean \u00b1 SEM 4,384 \u00b1 908 pg\/ml and 4,709 \u00b1 560 pg\/ml, respectively), but was higher in both groups than in healthy unrelated controls (515 \u00b1 88 pg\/ml). The healthy members of the multiplex families constitutively produced large amounts of IL\u201010 (3,080 \u00b1 311 pg\/ml; <jats:italic>P<\/jats:italic> &lt; 0.001 compared with healthy unrelated controls). This high IL\u201010 production was independent of age and sex, and was similar in first\u2010 and second\u2010degree relatives of SLE patients. The IL\u201010 was produced both by monocytes and by a subpopulation of B lymphocytes in SLE patients and in their relatives.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. The dysregulation of IL\u201010 production previously identified in SLE patients is also present in healthy members of families with several cases of SLE, and it may contribute to the immunologic abnormalities affecting relatives of SLE patients.<\/jats:p>","DOI":"10.1002\/art.1780400810","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:40:26Z","timestamp":1171456826000},"page":"1429-1435","source":"Crossref","is-referenced-by-count":96,"title":["Dysregulation of interleukin\u201010 production in relatives of patients with systemic lupus erythematosus"],"prefix":"10.1002","volume":"40","author":[{"given":"Luis","family":"Llorente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Richaud\u2010Patin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Couderc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Alarcon\u2010Segovia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Ruiz\u2010Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Alcocer\u2010Castillejos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Alcocer\u2010Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Granados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Bahena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Galanaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Emilie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.6.1755"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.27.4.311"},{"key":"e_1_2_1_4_2","first-page":"125","article-title":"Defective monocyte production of, and T lymphocyte response to, interleukin\u20101 in the peripheral blood of patients with systemic lupus erythematosus","volume":"54","author":"Alcocer\u2010Varela J","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110579"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.130.6.2651","article-title":"Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)","volume":"130","author":"Linker\u2010Israeli M","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112882"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.4049\/jimmunol.151.7.3914","article-title":"T cell\u2010antigen\u2010presenting cell interactions in human systemic lupus erythematosus: evidence for heterogeneous expression of multiple defects","volume":"151","author":"Via GS","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1890"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.3.839"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.4049\/jimmunol.150.11.4754","article-title":"Direct effect of IL\u201010 on subsets of human CD4+ T cells clones and resting T cells: specific inhibition of IL\u20102 production and proliferation","volume":"150","author":"De Waal Malefyt R","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.151.5.2390","article-title":"Inhibition of Langerhans cell antigen\u2010presenting function by IL\u201010: a role for IL\u201010 in induction of tolerance","volume":"151","author":"Enk AH","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90153-X"},{"key":"e_1_2_1_14_2","first-page":"421","article-title":"Spontaneous production of interleukin\u201010 by B lymphocytes and monocytes in systemic lupus erythematosus","volume":"4","author":"Llorente L","year":"1993","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371114"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390305"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339500400510"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01541225"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200303"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90334-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1996.0008"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220314"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381210"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81108-3"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80133-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339600500304"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117854"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341212"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114930"},{"key":"e_1_2_1_31_2","first-page":"578","article-title":"Identification and initial characterization of two polymorphisms in the human interleukin\u201010 promoter (abstract)","volume":"7","author":"Tountas NA","year":"1996","journal-title":"Eur Cytokine Netw"},{"issue":"9","key":"e_1_2_1_32_2","first-page":"S127","article-title":"Distribution of IL\u201010 promoter microsatellite alleles in systemic lupus erythematosus and rheumatoid arthritis (abstract)","volume":"39","author":"Eskdale J","year":"1996","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.10168"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.305"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.5.1213"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251110"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780400810","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780400810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T22:00:57Z","timestamp":1700776857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780400810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["10.1002\/art.1780400810"],"URL":"https:\/\/doi.org\/10.1002\/art.1780400810","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}