{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:16Z","timestamp":1761058636036},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2994,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1997,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To characterize, for the first time, periosteal new bone formation in a well\u2010established canine model of accelerated osteoarthritis (OA) with features of neuropathic arthropathy.<\/jats:p>Methods<\/jats:italic>. Seven dogs underwent left L4\u2010S1 dorsal root ganglionectomy (DRG), followed 3 weeks later by transection of the anterior cruciate ligament of the ipsilateral knee (ACLT). Eight weeks thereafter, a postmortem examination was performed to assess the severity of cartilage changes of OA and the formation of new bone on the distal femur and proximal tibia in the cruciate\u2010deficient limb.<\/jats:p>Results<\/jats:italic>. As described previously, extensive fullthickness ulceration of the articular cartilage was present in the unstable knee of every dog. The femoral shaft immediately proximal to the condyles in the unstable limb was consistently wider (mean \u00b1 SD diameter 22.4 \u00b1 2.2 mm) than that in the contralateral limb (19.9 \u00b1 1.3 mm; P<\/jats:italic> = 0.01). Xeroradiography and histologic examination of the distal femur revealed extensive formation of woven bone on the periosteal surfaces of the medial, lateral, and anterior aspects of the femoral shaft in the OA limb of every dog. These bony changes were not seen in radiographs of dogs that underwent DRG with the cruciate ligament left intact (n = 8) or of neurologically intact dogs that underwent ACLT (n = 7) and were examined 24 weeks after surgery.<\/jats:p>Conclusion<\/jats:italic>. Formation of new periosteal bone on the distal femur and tibia is a feature of this model of accelerated OA that is not seen in the conventional ACLT model of OA in the neurologically intact dog. This observation suggests that interruption of sensory input from the limb may affect the regulation of osteogenesis in the mechanically unstable joint.<\/jats:p>","DOI":"10.1002\/art.1780401005","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:15:21Z","timestamp":1171455321000},"page":"1756-1759","source":"Crossref","is-referenced-by-count":2,"title":["Periosteal new bone formation in a canine neuropathic model of osteoarthritis"],"prefix":"10.1002","volume":"40","author":[{"given":"Stephen L.","family":"Myers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Widmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330316"},{"key":"e_1_2_1_3_2","volume-title":"Diagnosis of Bone and Joint Disorders","author":"Resnick D","year":"1995"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0033-8389(22)01344-6","article-title":"The neuropathic joint: a neurovascular bone disorder","volume":"19","author":"Brower AC","year":"1981","journal-title":"Radiol Clin North Am"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198567040-00010"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360817"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351007"},{"key":"e_1_2_1_8_2","first-page":"36","article-title":"Radiographic imaging of rodents using a portable mammographic system","volume":"34","author":"Vogelweid CM","year":"1995","journal-title":"Contemp Top"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.1.12"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(89)90057-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090113"},{"key":"e_1_2_1_12_2","first-page":"2113","article-title":"Serial kinematic analysis of the canine knee after L4\u2010S1 dorsal root ganglionectomy: implications for the cruciate deficiency model of osteoarthritis","volume":"21","author":"Vilensky JA","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(82)90062-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(97)80033-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319037"},{"key":"e_1_2_1_16_2","first-page":"1252","article-title":"Innervation of bone from healthy and arthritic rats by substance P and calcitonin gene\u2010related peptide containing sensory fibers","volume":"19","author":"Hukkanen M","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90588-7"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780401005","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780401005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:38:23Z","timestamp":1700757503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780401005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1002\/art.1780401005"],"URL":"https:\/\/doi.org\/10.1002\/art.1780401005","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}