{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:38:14Z","timestamp":1760981894050},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2994,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[1997,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:italic>. To characterize muscle metabolic anomalies associated with polymyalgia rheumatica (PMR) using P\u201031 magnetic resonance spectroscopy (MRS).<\/jats:p>Methods<\/jats:italic>. Seventeen patients with PMR and 9 age\u2010matched control subjects were investigated. The forearm flexor muscles were examined by P\u201031 MRS in a 4.7 T superconducting horizontal magnet (Biospec Bruker 47\/30) during a rest\u2010exercise\u2010recovery protocol. The intracellular pH and the relative concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), ATP, and phosphomonoesters were measured every minute during the protocol. Based on the PCr and pH timedependent changes during exercise and recovery, the rates of ATP production from PCr hydrolysis, glycogenolysis, and aerobic metabolism were calculated for each minute of exercise.<\/jats:p>Results<\/jats:italic>. At rest, the metabolic parameters [PCr]: [Pi], pH, and [PCr]:[ATP] were not significantly different between the PMR patients and the control subjects. During exercise, the energetic cost and the contribution of anaerobic and oxidative pathways to energy supply were similar in the 2 groups, as were the recovery kinetics of the phosphorylated compounds and pH.<\/jats:p>Conclusion<\/jats:italic>. Muscle MRS does not confirm the findings of histologic and biochemical studies that suggest an alteration of mitochondrial function in PMR. No other modifications in glycolytic or glycogenolytic pathways or in proton handling were found that could indicate an alteration of muscle energetics in patients with PMR.<\/jats:p>","DOI":"10.1002\/art.1780401014","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:15:21Z","timestamp":1171455321000},"page":"1817-1822","source":"Crossref","is-referenced-by-count":11,"title":["P\u201031 Magnetic resonance spectroscopy demonstrates unaltered muscle energy utilization in polymyalgia rheumatica"],"prefix":"10.1002","volume":"40","author":[{"given":"J. P.","family":"Mattei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bendahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Erkintalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Harle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Weiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Roux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Cozzone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"101","article-title":"Muscle pathology in rheumatoid arthritis, polymyalgia rheumatica, and polymyositis","volume":"94","author":"Brooke MH","year":"1972","journal-title":"Arch Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711370303"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370411"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-7-199410010-00003"},{"key":"e_1_2_1_6_2","first-page":"140","article-title":"Polymyalgia rheumatica","volume":"1","author":"Hunder GG","year":"1974","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90108-N"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2675"},{"key":"e_1_2_1_9_2","first-page":"43","article-title":"Quantitative interpretation of bioenergetic data from P\u201031 and H\u20101 magnetic resonance spectroscopic studies of skeletal muscle\u2014an analytical review","volume":"10","author":"Kemp GJ","year":"1994","journal-title":"Magn Reson Q"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80472-U"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300116"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370519"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380111"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.2.264"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90073-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390719"}],"container-title":["Arthritis & Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780401014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780401014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:37:36Z","timestamp":1700757456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780401014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1002\/art.1780401014"],"URL":"https:\/\/doi.org\/10.1002\/art.1780401014","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}