{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:33:43Z","timestamp":1786473223784,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2994,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. Not uncommonly, some children with systemic\u2010onset juvenile rheumatoid arthritis (JRA) have persistently active disease with joint destruction and profound growth delay despite maximum treatment with known medications. Based on previous observations of improvement in synovitis following intravenous (IV) cyclophosphamide (CYC) and methylprednisolone (MP) treatments, a group of children with severe systemic\u2010onset JRA was treated in an attempt to control active synovitis and to allow tapering of corticosteroids.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Four patients with systemic\u2010onset JRA were continued on a daily regimen of nonsteroidal antiinflammatory agents and prednisone, with a weekly subcutaneous dose of methotrexate (1 mg\/kg). In addition, 1 patient continued receiving sulfasalazine and 1 patient remained on a regimen of sulfasalazine and hydroxychloroquine. Patients received 6\u201310 monthly treatments of IV CYC (500\u20131,000 mg\/m<jats:sup>2<\/jats:sup>) and MP (30 mg\/kg; 1 gm maximum) accompanied by IV mesna and large amounts of IV fluids. Subsequent treatments were given once every 2\u20133 months.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. After 12\u201320 IV pulses of CYC, all patients showed improvement, and 3 achieved remission of disease. All were able to discontinue corticosteroid use and all had an increase in linear growth.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Monthly IV pulse CYC treatments can be useful to control disease in selected children with severe, destructive JRA.<\/jats:p>","DOI":"10.1002\/art.1780401019","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:15:21Z","timestamp":1171455321000},"page":"1852-1855","source":"Crossref","is-referenced-by-count":67,"title":["Trial of intravenous pulse cyclophosphamide and methylprednisolone in the treatment of severe systemic\u2010onset juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"40","author":[{"given":"Carol A.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Sherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900430001001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0889-857X(21)00134-4","article-title":"Juvenile rheumatoid arthritis: outcome and treatment for the 1990s","volume":"17","author":"Wallace CA","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_1_4_2","first-page":"612","article-title":"Repetitive use of pulse therapy with methylprednisolone and cyclophosphamide in addition to oral methotrexate in children with systemic juvenile rheumatoid arthritis: preliminary results of a long\u2010term study","volume":"19","author":"Shaikov AV","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241012"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-4-199702150-00005"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00869818"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00780.x"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780401019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780401019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:38:15Z","timestamp":1700757495000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780401019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1002\/art.1780401019"],"URL":"https:\/\/doi.org\/10.1002\/art.1780401019","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}