{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:34:13Z","timestamp":1772969653088,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2963,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To examine whether human retrovirus\u20105 (HRV\u20105) infection is associated with Sj\u00f6gren's syndrome.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Salivary gland DNA was tested by nested polymerase chain reaction (PCR) for HRV\u20105 proviral DNA. Rigorous precautions were taken to prevent false\u2010positive results from PCR contamination. Positive samples were confirmed by testing with an additional independent set of primers and were then sequenced.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Ninety\u2010two samples were examined (55 from Sj\u00f6gren's syndrome patients, 37 from non\u2010Sj\u00f6gren's syndrome patients), 2 of which were positive. One was from a patient who had sicca symptoms but who did not satisfy the criteria for a diagnosis of Sj\u00f6gren's syndrome. The other was from a patient with secondary Sj\u00f6gren's syndrome. Owing to the extremely low virus load in minor salivary glands, the number of HRV\u20105\u2014infected patients may be underestimated. In total, 3 different sequences of HRV\u20105 were identified which were 98% identical to the original sequence but which displayed variations between and within individuals.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. This is the first study to systematically seek a disease association with HRV\u20105, although with this method, an association with Sj\u00f6gren's syndrome was not identified.<\/jats:p>","DOI":"10.1002\/art.1780401114","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:11:51Z","timestamp":1171455111000},"page":"2016-2021","source":"Crossref","is-referenced-by-count":26,"title":["Human retrovirus\u20105 proviral DNA is rarely detected in salivary gland biopsy tissues from patients with Sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"40","author":[{"given":"Shirley P.","family":"Rigby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J. W.","family":"Venables","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin A.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(95)80025-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92085-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199604000-00006"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90630-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330603"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.11.735"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(92)90104-V"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1701273"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.4.2866-2872.1997"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/380201a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360309"},{"key":"e_1_2_1_13_2","volume-title":"Wisconsin Package, Version 8","author":"Genetics Computer Group","year":"1994"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0966-842X(96)10023-8"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780401114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780401114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:42:10Z","timestamp":1700757730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780401114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1002\/art.1780401114"],"URL":"https:\/\/doi.org\/10.1002\/art.1780401114","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}