{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:16:06Z","timestamp":1771503366683,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2963,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>.To study whether peptides derived from the HLA\u2010B27 molecule sequence can stimulate peripheral blood T lymphocytes (PBL) from patients with HLA\u2010B27\u2010associated spondylarthropathies.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>.PBL from 55 HLA\u2010B27+ patients with ankylosing spondylitis (AS), 28 HLA\u2010B27+ patients with other spondylarthropathies, 7 rheumatoid arthritis patients, and 30 HLA\u2010B27+ and 22 HLA\u2010B27\u2010 healthy controls were tested in lymphocyte proliferation assays with 4 synthetic peptides derived from the HLA\u2010B*2705 molecule.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. A 13\u2010mer peptide (B27PA) induced significant proliferative responses in 17 of the 55 AS patients (stimulation index [SI] 2.5\u201317.5), as well as in 3 of the HLA\u2010B27+ healthy controls (SI 2.5\u20139.8). Another 13\u2010mer peptide (B27PC) induced PBL proliferation (SI 2.7\u20135.5) in 10 AS patients and in some donors of the control groups. In B27PA\u2010specific T cell lines, an expansion of cells positive for the \u03b3\/\u03b4 T cell receptor could be demonstrated.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. These results indicate that HLA\u2010B27\u2010derived peptides can be recognized as autoantigens by PBL of HLA\u2010B27+ AS patients and B27+ healthy controls. Recent infections preceding the manifestation of AS may be involved in this process of anti\u2010self major histocompatibility complex reactivity.<\/jats:p>","DOI":"10.1002\/art.1780401118","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:11:51Z","timestamp":1171455111000},"page":"2047-2054","source":"Crossref","is-referenced-by-count":39,"title":["HLA\u2010B27\u2010derived peptides as autoantigens for T lymphocytes in ankylosing spondylitis"],"prefix":"10.1002","volume":"40","author":[{"given":"Elisabeth","family":"M\u00e4rker\u2010Hermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Hermann Meyer 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