{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:07:23Z","timestamp":1790489243173,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2933,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. The goal of this study was to evaluate the physical and psychosocial impact of juvenile rheumatoid arthritis (JRA) among a population\u2010based cohort of adults who had the disease during childhood, compared with a control cohort of subjects with no history of JRA.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. The Rochester Epidemiology Project database was used to identify all cases of JRA (based on the American College of Rheumatology [formerly, the American Rheumatism Association] 1977 criteria) among Rochester, Minnesota residents first diagnosed between January 1, 1960 and December 31, 1993. Controls were age\u2010 and sex\u2010matched to the cases as of the date of diagnosis of JRA. A pretested postal survey was mailed to all adult cases (whose date of birth was before December 31, 1975) and matched controls from the same population, to obtain information on socioeconomic issues and functional status (using the Health Assessment Questionnaire and the Health Status Questionnaire). The complete medical records of all cases and controls were reviewed to obtain information on demographics and clinical manifestations of JRA.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Of the 50 eligible cases, 44 (88%) responded to the survey. There were 102 age\u2010 and sexmatched controls (2\u20133 per case) who responded to the survey. Seventy\u2010three percent of the cases had pauciarticular\u2010onset JRA, 16% had polyarticular\u2010onset JRA, and 11% had systemic\u2010onset JRA. Average followup was 24.7 years and 24.5 years after the index date for cases and controls, respectively. Greater disability (<jats:italic>P<\/jats:italic> = 0.0002), more bodily pain (<jats:italic>P<\/jats:italic> = 0.0002), increased fatigue (<jats:italic>P<\/jats:italic> = 0.0112), poorer health perception (<jats:italic>P<\/jats:italic> = 0.0004), and decreased physical functioning (<jats:italic>P<\/jats:italic> = 0.0002) were reported by the cases compared with the controls. JRA cases reported significantly lower rates of employment (<jats:italic>P<\/jats:italic> = 0.015) and lower levels of exercise (<jats:italic>P<\/jats:italic> = 0.0002) than did controls. Level of educational achievement, annual income, health insurance status, and rate of pregnancy and childbirth were similar for both cases and controls.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Adults who have had JRA during childhood experience long\u2010term physical and psychosocial impairment.<\/jats:p>","DOI":"10.1002\/art.1780401219","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:10:55Z","timestamp":1171455055000},"page":"2235-2240","source":"Crossref","is-referenced-by-count":137,"title":["Psychosocial outcomes and health status of adults who have had juvenile rheumatoid arthritis. A controlled, population\u2010based study"],"prefix":"10.1002","volume":"40","author":[{"given":"Lynne S.","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey M.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"O'Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherine E.","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"279","article-title":"Prognosis of juvenile rheumatoid arthritis","volume":"20","author":"Hanson V","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_3_2","first-page":"891","article-title":"Juvenile rheumatoid arthritis: outcome and treatment for the 1990's","volume":"17","author":"Wallace CA","year":"1991","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.39.208.576"},{"key":"e_1_2_1_5_2","first-page":"23","article-title":"A prognostic study of juvenile rheumatoid arthritis","volume":"166","author":"Laaksonen AL","year":"1966","journal-title":"Acta Paediatric Scand"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90076-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.1.25"},{"key":"e_1_2_1_8_2","first-page":"790","article-title":"Juvenile rheumatoid arthritis: follow\u2010up into adulthood\u2014medical, sexual, and social status","volume":"76","author":"Hill RH","year":"1976","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0307-742X(21)00183-1","article-title":"Prognosis in juvenile chronic polyarthritis","volume":"2","author":"Ansell BM","year":"1976","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442095"},{"key":"e_1_2_1_11_2","first-page":"909","article-title":"Prognostic factors in juvenile rheumatoid arthritis","volume":"9","author":"Dequeker J","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_1_12_2","first-page":"17","article-title":"Juvenile rheumatoid arthritis: long\u2010term management and prognosis","volume":"6","author":"Calabro JJ","year":"1989","journal-title":"J Musculoskeletal Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.3.266"},{"issue":"2","key":"e_1_2_1_14_2","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390817"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_1_18_2","first-page":"I52","article-title":"Second natural history study of congenital heart defects: quality of life of patients with aortic stenosis, pulmonary stenosis, or ventricular septal defect","volume":"87","author":"Gersony WM","year":"1993","journal-title":"Circulation"},{"issue":"38","key":"e_1_2_1_19_2","first-page":"1","article-title":"Psychosocial factors related to rheumatic diseases in childhood","volume":"20","author":"Miller JJ","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02939883"},{"key":"e_1_2_1_21_2","first-page":"290","article-title":"Aspiration and achievement\u2014a study of one hundred patients with juvenile rheumatoid arthritis","volume":"33","author":"Morse J","year":"1972","journal-title":"Rehabil Lit"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1037\/0278-6133.6.4.343","article-title":"Psychosocial adaptation in juvenile rheumatic disease: a controlled evaluation","volume":"6","author":"Billings AG","year":"1987","journal-title":"Health Psychol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90169-4"},{"issue":"33","key":"e_1_2_1_24_2","first-page":"23","article-title":"Transition\/job readiness for adolescents with juvenile arthritis and other chronic illness","volume":"19","author":"White PH","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80433-2"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340714"}],"container-title":["Arthritis &amp; 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