{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:04:25Z","timestamp":1761609865003},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":2933,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the role of HLA\u2010DRB1 genotypes in the development and progression of the rheumatoid arthritis (RA) disease process.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Patients with polyarthritis of &lt;1 year in duration were consecutively enrolled in the study. Other inclusion criteria were no diagnosis of inflammatory diseases other than RA, and no history of taking disease\u2010modifying antirheumatic drugs or steroids. Patients were evaluated every 4 weeks, and radiographs of the hands\/wrists and feet were taken at presentation and 1 year later. HLA\u2010DRB1 genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism methods.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. We enrolled 198 patients (median disease duration 5.0 months) and 150 controls. The frequency of individuals with DRB1*0405 and *0410 was significantly higher in the patients than in the controls. Homozygous states for DRB1 alleles with the RArelated shared epitope (SE) were associated with increased susceptibility for the development of polyarthritis (odds ratio 3.4, 95% confidence interval 1.5\u20137.7). None of the DRB1 alleles or SE genotypes correlated with the presence of bone erosion at presentation or 1 year later.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. DRB1 alleles with SEs were associated with the development of polyarthritis but not with early radiographic progression of the disease process.<\/jats:p>","DOI":"10.1002\/art.1780401220","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T12:10:55Z","timestamp":1171455055000},"page":"2241-2247","source":"Crossref","is-referenced-by-count":26,"title":["Lack of association of hla\u2010drb1 genotype with radiologic progression in japanese patients with early rheumatoid arthritis"],"prefix":"10.1002","volume":"40","author":[{"given":"Kenshi","family":"Higami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Hakoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Kashiwazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804202981602"},{"key":"e_1_2_1_3_2","first-page":"136","article-title":"HLA antigens in palindromic rheumatism, non\u2010erosive rheumatoid arthritis and classical rheumatoid arthritis","volume":"11","author":"Gran JT","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.8.627"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780301102"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/368215a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1847"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.4.613"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.7.539"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-10-801"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115814"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117900"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.9.587"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6866.1387"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370809"},{"key":"e_1_2_1_16_2","first-page":"2027","article-title":"HLA\u2010DR1, DR4 and DRB1 disease related subtypes in rheumatoid arthritis: association with susceptibility but not severity in a city wide community based study","volume":"22","author":"Suarez\u2010Almazor ME","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.1.34"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1990.tb01751.x"},{"key":"e_1_2_1_20_2","first-page":"585","article-title":"HLA heterozygosity contributes to susceptibility to rheumatoid arthritis","volume":"51","author":"Wordsworth P","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_21_2","first-page":"1032","article-title":"HLA\u2010DRB1*0401\/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity","volume":"22","author":"MacGregor A","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(82)90057-X"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.6.2263"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.7.517"},{"key":"e_1_2_1_25_2","first-page":"1363","article-title":"HLA\u2010DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the \u201cshared epitope\u201d hypothesis may not apply","volume":"23","author":"Teller K","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_1_26_2","first-page":"2005","article-title":"The prognosis of rheumatoid arthritis and undifferentiated polyarthritis syndrome in the clinic: a study of 1141 patients","volume":"20","author":"Wolfe F","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381013"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391105"}],"container-title":["Arthritis &amp; 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