{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:19:36Z","timestamp":1791973176839,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,5]],"date-time":"2004-03-05T00:00:00Z","timestamp":1078444800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine magnetic resonance imaging\u2013derived T2 relaxation times in the weight\u2010bearing cartilage of the distal femur in healthy children and in children with juvenile rheumatoid arthritis (JRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      T2 relaxation time maps were created for 39 girls (ages 4.9\u201310.9 years), 21 of whom were considered healthy and 18 of whom had JRA. The spatial distribution of T2 relaxation times for the distal femoral weight\u2010bearing cartilage (including epiphyseal and articular cartilage) was mapped for each group as a whole. Average data sets for each group were then compared using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests to detect differences between the 2 populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The spatial distribution of T2 relaxation time values was nearly identical in the 2 groups, with a concave curve that was highest near the subchondral bone and articular surfaces. The average T2 relaxation times were significantly higher in the girls with JRA than in the group of healthy girls (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The finding of an increased average T2 relaxation time in the children with JRA suggests that T2 relaxation time maps may reflect cartilage microstructure differences that occur in JRA. T2 relaxation time mapping may allow for early detection of cartilage changes and provide an objective, quantitative method of monitoring disease progression, with the long\u2010term potential to guide therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.20062","type":"journal-article","created":{"date-parts":[[2004,3,10]],"date-time":"2004-03-10T03:00:43Z","timestamp":1078887643000},"page":"901-905","source":"Crossref","is-referenced-by-count":54,"title":["Magnetic resonance imaging evaluation of the effects of juvenile rheumatoid arthritis on distal femoral weight\u2010bearing cartilage"],"prefix":"10.1002","volume":"50","author":[{"given":"Amanda C.","family":"Kight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Dardzinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Laor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Brent","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(98)80014-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0889-857X(21)00134-4","article-title":"Juvenile rheumatoid arthritis: outcome and treatment for the 1990s","volume":"17","author":"Wallace CA","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361007"},{"issue":"2","key":"e_1_2_6_5_2","first-page":"195","article-title":"Current proposed revision of the JRA criteria","volume":"20","author":"JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1302\/0301-620X.58B1.131804","article-title":"Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog","volume":"58","author":"McDevitt CA","year":"1976","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_6_7_2","series-title":"Joint destruction in arthritis and osteoarthritis. Agents and actions supplements","author":"Van den Berg W","year":"1993"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310306"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-203-43569"},{"key":"e_1_2_6_10_2","first-page":"1747","article-title":"Osteoarthritis in rhesus macaque knee joint: quantitative magnetic resonance imaging tissue characterization of articular cartilage","volume":"22","author":"Gahunia HK","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(99)00144-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356643"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2251011461"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1580::AID-ANR23>3.0.CO;2-G"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200005)43:5<676::AID-MRM9>3.0.CO;2-X"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0847"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.3.r00mr20705"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.20062","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.20062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T16:13:01Z","timestamp":1700755981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.20062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1002\/art.20062"],"URL":"https:\/\/doi.org\/10.1002\/art.20062","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}