{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:54:29Z","timestamp":1791258869224,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,5]],"date-time":"2004-02-05T00:00:00Z","timestamp":1075939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the osteologic findings associated with osteoarthritis (OA) of a variety of joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed visual examination of 563 skeletons of which \u226580% of the skeleton was available, from an archaeologic site in England. The surfaces and margins of several different joints (shoulders, elbows, wrists, hips, hands, knees, and ankles) were studied for evidence of eburnation and osteophytes, respectively, and the entire skeleton was examined for evidence of generalized enthesophyte formation. Associations between changes in different joint sites and between enthesophyte formation and evidence of OA were sought.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eburnation and osteophyte formation at the hand, hip, and knee were strongly associated with eburnation and osteophytes at other joint sites not commonly thought to be prone to OA, including the elbow and wrist. Only the ankle was rarely involved. There was also a strong relationship between both bone eburnation and osteophytes and generalized enthesophyte formation. These findings remained statistically significant after adjustment for the age, sex, and historical period of the skeletons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that skeletal OA is more widespread in the body than is apparent from clinical studies and are consistent with other data suggesting that OA is a disease that is primarily dependent on systemic predisposition to a particular type of bone response to mechanical stress.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20136","type":"journal-article","created":{"date-parts":[[2004,2,9]],"date-time":"2004-02-09T18:29:18Z","timestamp":1076351358000},"page":"452-457","source":"Crossref","is-referenced-by-count":88,"title":["Is osteoarthritis a systemic disorder of bone?"],"prefix":"10.1002","volume":"50","author":[{"given":"Juliet","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Shepstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dieppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2,5]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"Rheumatology","first-page":"8.8.1","author":"Bullough PG","year":"1998"},{"key":"e_1_2_6_3_2","volume-title":"The pathology of articular and spinal diseases","author":"Collins DH","year":"1949"},{"key":"e_1_2_6_4_2","series-title":"Rheumatology","first-page":"8.4.1","author":"Dieppe P","year":"1998"},{"key":"e_1_2_6_5_2","first-page":"3","article-title":"Atlas of individual radiographic features of osteoarthritis","volume":"3","author":"Altman M","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.25.1.1"},{"key":"e_1_2_6_7_2","first-page":"1581","article-title":"Analysis of disability in knee osteoarthritis: relationship with age and psychological variables but not with radiographic score","volume":"18","author":"Salaffi F","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM189701281360402"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4751.181"},{"key":"e_1_2_6_10_2","first-page":"1938","article-title":"Generalised osteoarthritis in women: pattern of joint involvement and approaches to defintion for epidemiological studies","volume":"23","author":"Cooper C","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<483::AID-ANR13>3.0.CO;2-O"},{"key":"e_1_2_6_12_2","volume-title":"Barton\u2010on\u2010Humbar Excavation","year":"2001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0047-2484(80)90061-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.2.85"},{"key":"e_1_2_6_15_2","volume-title":"A field guide to joint disease in archaeology","author":"Rogers J","year":"1995"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4403(87)90005-7"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197003000-00035"},{"key":"e_1_2_6_18_2","first-page":"1","volume-title":"Osteoarthritis","author":"Flores RH","year":"1998"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00016"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01889359"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.9.659"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.1.8"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(97)80002-9"},{"key":"e_1_2_6_24_2","first-page":"1785","article-title":"Determinants of pain severity in knee osteoarthritis","volume":"26","author":"Creamer P","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.4.1025"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210206"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.3.158"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(97)80005-2"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI867"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.8.557"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003086-199302000-00004","article-title":"Does osteoarthritis depend on growth of the mineralised layer of cartilage?","volume":"287","author":"Hulth A","year":"1993","journal-title":"Clin Orthop"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390111"}],"container-title":["Arthritis &amp; 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