{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:17:52Z","timestamp":1790839072491,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,4,5]],"date-time":"2004-04-05T00:00:00Z","timestamp":1081123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the frequency and clinical presentation of biopsy\u2010proven giant cell arteritis (GCA) patients who do not exhibit overt clinical vascular manifestations. To assess whether differences exist between this group of patients and the rest of biopsy\u2010proven GCA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of biopsy\u2010proven GCA patients diagnosed from 1981 through 2001 at the single hospital for a well\u2010defined population of almost 250,000 people. Patients were considered as having no evident vascular involvement if cranial ischemic manifestations or other vascular complications of GCA were not present at the time of diagnosis or during at least 12 months' followup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 1981 and 2001, 210 patients from the Lugo region of northwest Spain were diagnosed with biopsy\u2010proven GCA. Eleven patients did not show overt vascular manifestations of GCA. Nine of them presented with polymyalgia rheumatica (PMR) and another 2 fulfilled criteria for fever of unknown origin. Patients without clinically evident vascular involvement had a significantly longer delay to diagnosis than those with vascular manifestations. Also, PMR manifestations were more frequently observed in this group of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biopsy\u2010proven GCA without clinically evident vascular involvement is not exceptional. Despite having a longer delay to diagnosis, these patients constitute a more benign subgroup of GCA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20231","type":"journal-article","created":{"date-parts":[[2004,4,5]],"date-time":"2004-04-05T16:04:17Z","timestamp":1081181057000},"page":"274-277","source":"Crossref","is-referenced-by-count":41,"title":["Giant cell arteritis without clinically evident vascular involvement in a defined population"],"prefix":"10.1002","volume":"51","author":[{"given":"Miguel A.","family":"Gonzalez\u2010Gay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garcia\u2010Porrua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Amor\u2010Dorado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70232-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230605"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780241113"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00151.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199909000-00002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200009000-00001"},{"key":"e_1_2_5_8_2","first-page":"1326","article-title":"The spectrum of polymyalgia rheumatica in Northwestern Spain: incidence and analysis of variables associated with relapse in a ten year study","volume":"26","author":"Gonzalez\u2010Gay MA","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-672"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199711000-00002"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370411"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar293"},{"key":"e_1_2_5_13_2","first-page":"1750","article-title":"Polymyalgia rheumatica in biopsy\u2010proven giant cell arteritis does not constitute a different subset but differs from isolated polymyalgia rheumatica","volume":"25","author":"Gonzalez\u2010Gay MA","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.4.367"},{"key":"e_1_2_5_15_2","first-page":"502","article-title":"Intercellular adhesion molecule\u20101 gene polymorphisms in isolated polymyalgia rheumatica","volume":"29","author":"Amoli MM","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1978.tb03333.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90675-3"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199801)41:1<26::AID-ART4>3.0.CO;2-0"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1427::AID-ANR35>3.0.CO;2-P"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65175-9"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030185.67510.C0"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.20231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.20231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T15:07:56Z","timestamp":1696691276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.20231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,5]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4,15]]}},"alternative-id":["10.1002\/art.20231"],"URL":"https:\/\/doi.org\/10.1002\/art.20231","archive":["Portico"],"relation":{},"ISSN":["0893-7524","1529-0123"],"issn-type":[{"value":"0893-7524","type":"print"},{"value":"1529-0123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,5]]}}}