{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:58:22Z","timestamp":1789444702920,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,6,3]],"date-time":"2004-06-03T00:00:00Z","timestamp":1086220800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult\u2010onset Still's disease. Interleukin\u201018 (IL\u201018) in particular has been reported to be a candidate for the key cytokine in both diseases; however, the origin of IL\u201018 is unclear. To clarify the origin, we investigated specimens from various organs obtained during autopsy of a child with systemic JIA and macrophage activation syndrome, using immunohistochemical staining. Our results showed a high number of cells expressing IL\u201018 in the bone marrow but not in the other organs. This finding suggests that bone marrow is the origin of increased serum IL\u201018 and raises the possibility that other proinflammatory cytokines are also induced by IL\u201018 in bone marrow in this disease. Bone marrow may be an essential organ in the pathogenesis of systemic JIA.<\/jats:p>","DOI":"10.1002\/art.20268","type":"journal-article","created":{"date-parts":[[2004,6,3]],"date-time":"2004-06-03T17:02:30Z","timestamp":1086282150000},"page":"1935-1938","source":"Crossref","is-referenced-by-count":75,"title":["Increased interleukin\u201018 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage\u2010activation syndrome"],"prefix":"10.1002","volume":"50","author":[{"given":"Nobuaki","family":"Maeno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syuji","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Imanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimie","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kuriwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,6,3]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"203","article-title":"Is systemic juvenile rheumatoid arthritis an interleukin 6 mediated disease?","volume":"25","author":"De Benedetti F","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10389"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200103)44:3<550::AID-ANR103>3.0.CO;2-5"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200107)44:7<1716::AID-ART298>3.0.CO;2-I"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/378088a0"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200107)44:7<1481::AID-ART268>3.0.CO;2-1"},{"key":"e_1_2_4_8_2","first-page":"451","article-title":"Macrophage activation syndrome and rheumatic disease in childhood: a report of four new cases","volume":"11","author":"Stephan JL","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_4_9_2","first-page":"2482","article-title":"Remission of juvenile rheumatoid arthritis after infection with parvovirus B19","volume":"26","author":"Bateman HE","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_4_10_2","first-page":"1606","article-title":"Remission of juvenile rheumatoid arthritis with varicella infection","volume":"26","author":"Saulsbury FT","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009749950155652"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199702)54:2<166::AID-AJH13>3.0.CO;2-D"},{"key":"e_1_2_4_13_2","first-page":"830","article-title":"Remarkable elevation of interleukin 6 and interleukin 8 levels in the bone marrow serum of patients with rheumatoid arthritis","volume":"21","author":"Tanabe M","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_4_14_2","first-page":"1504","article-title":"Elevated levels of inflammatory cytokines in bone marrow of patients with rheumatoid arthritis and anemia of chronic disease","volume":"24","author":"Jongen\u2010Lavrencic M","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.9.854"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(00)90211-2"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.110"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01622-4"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg074"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05399-9"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.7.702"}],"container-title":["Arthritis &amp; 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