{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:28Z","timestamp":1790175088855,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T00:00:00Z","timestamp":1089072000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate a possible pathogenic role of cytokines in Beh\u00e7et's disease (BD) by focusing on the analysis of cytokine gene expression within mucocutaneous BD lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group comprised 20 patients with active BD. In this group, a set of chemokines as well as Th1 and Th2 cytokines in biopsy specimens obtained from oral and genital ulcers, pseudofolliculitis lesions, and lesions at the site of pathergy testing were studied using real\u2010time quantitative reverse transcriptase\u2013polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed important increases in the expression of interleukin\u20108 (IL\u20108) (\u223c700\u2010fold), monocyte chemoattractant protein 1 (\u223c65\u2010fold), interferon\u2010\u03b3 (\u223c71\u2010fold), and IL\u201012 (\u223c69\u2010fold) messenger RNA in BD lesions compared with normal skin. Except for IL\u201010 (\u223c75\u2010fold increase), Th2 cytokines (i.e., IL\u20104 and IL\u201013) were absent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest a direct role of Th1 lymphocytes in the pathogenesis of mucocutaneous BD lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20334","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T15:05:14Z","timestamp":1089126314000},"page":"2291-2295","source":"Crossref","is-referenced-by-count":131,"title":["Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Beh\u00e7et's disease"],"prefix":"10.1002","volume":"50","author":[{"given":"M.","family":"Ben Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Houman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dellagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Louzir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,6]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"483","article-title":"Immunopathogenesis of Beh\u00e7et's disease","volume":"150","author":"Lehner T","year":"1999","journal-title":"Ann Med Interne (Paris)"},{"issue":"19","key":"e_1_2_5_3_2","first-page":"S6","article-title":"Beh\u00e7et's disease: an update on its pathogenesis","author":"Gul A","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09629350220131935"},{"key":"e_1_2_5_6_2","first-page":"321","article-title":"Cytokines in Beh\u00e7et's disease","volume":"23","author":"Sayinalp N","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(95)00439-4"},{"key":"e_1_2_5_8_2","first-page":"904","article-title":"Enhanced interleukin 8 secretion in circulation of patients with Beh\u00e7et's disease","volume":"22","author":"Al\u2010Dalaan A","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_5_9_2","first-page":"1544","article-title":"Overproduction of monocyte derived tumor necrosis factor \u03b1, interleukin (IL) 6, IL\u20108 and increased neutrophil superoxide generation in Beh\u00e7et's disease: a comparative study with familial Mediterranean fever and healthy subjects","volume":"20","author":"Mege JL","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1967::AID-ANR24>3.0.CO;2-Z"},{"key":"e_1_2_5_11_2","first-page":"510","article-title":"Serum levels of Th2 cytokines IL\u20104 and IL\u201010 in Beh\u00e7et's disease","volume":"26","author":"Mantas C","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_5_12_2","first-page":"329","article-title":"Divergent cytokine production profile in Beh\u00e7et's disease: altered Th1\/Th2 cell cytokine pattern","volume":"25","author":"Raziuddin S","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","first-page":"128","article-title":"Systemic levels of the T cell regulatory cytokines IL\u201010 and IL\u201012 in Beh\u00e7et's disease: soluble TNFR\u201075 as a biological marker of disease activity","volume":"24","author":"Turan B","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_5_14_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.10.986"},{"key":"e_1_2_5_16_2","unstructured":"Ben AhmedM HoumanH MiledM DellagiK LouzirH.Cytokines involved in Beh\u00e7et's disease. 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