{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:49:07Z","timestamp":1761540547820,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,9]],"date-time":"2004-09-09T00:00:00Z","timestamp":1094688000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Technology, Sports, and Culture, Japan","doi-asserted-by":"crossref","award":["Young Scientists (A) (15689016)"],"award-info":[{"award-number":["Young Scientists (A) (15689016)"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether eyedrop administration of an anti\u2010CD4 monoclonal antibody (mAb) is effective in the treatment of Sj\u00f6gren's syndrome (SS) using a mouse model of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The anti\u2010CD4 mAb was administered daily into the eyes of mice with SS from ages 4 to 8 weeks or ages 10 to 12 weeks. During treatment, tear volume was monitored and after final treatment, histologic features of the lacrimal and salivary glands, the phenotypes and function of T cells, and serum titers of anti\u2013\u03b1\u2010fodrin antibody were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eyedrop administration of anti\u2010CD4 mAb before the onset of SS prevented the autoimmune pathology seen in the lacrimal glands but not that in the salivary glands. Furthermore, eyedrop administration of anti\u2010CD4 mAb after the development of SS inhibited mononuclear cell infiltration and the destruction of parenchyma only in the lacrimal glands. Eyedrop administration of anti\u2010CD4 mAb suppressed the local activation of CD4+ T cells rather than deleting CD4+ T cells, which reduced the expansion of pathologic CD4+ T cells against \u03b1\u2010fodrin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrate the remarkable efficacy of anti\u2010CD4 mAb eyedrops in the treatment of SS eye symptoms, which illustrates a new antibody\u2010based therapeutic strategy for patients with eye problems caused by SS as well as other diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20472","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T08:54:27Z","timestamp":1095152067000},"page":"2903-2910","source":"Crossref","is-referenced-by-count":14,"title":["Effective treatment of a mouse model of Sj\u00f6gren's syndrome with eyedrop administration of anti\u2010CD4 monoclonal 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