{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:43:29Z","timestamp":1770133409190,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether radiologic spine disc degeneration is associated with increased type II collagen (CII) degradation products in the urine of postmenopausal women, independently of radiologic knee osteoarthritis (OA) and clinical hand OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group comprised 324 postmenopausal women ages 58\u201394 years who had no treatment or disease that could alter bone metabolism. Lateral radiographs of the thoracic and lumbar spine were obtained in each woman and scored for disc space narrowing (DSN) and osteophytes. Fixed\u2010flexion posteroanterior radiographs of the knee were obtained to assess femorotibial knee OA. In all women, hand OA was assessed by clinical examination, and the level of urinary C\u2010terminal crosslinking telopeptide of CII (CTX\u2010II), a biologic marker of CII degradation, was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalences of radiographic lumbar and thoracic spine disc degeneration, knee OA, and clinical hand OA were 84%, 88%, 35%, and 58%, respectively. After adjustment for age and body mass index (BMI), patients with lumbar spine DSN grade \u22651 had, on average, 34% higher CTX\u2010II levels compared with the other women (<jats:italic>P<\/jats:italic> = 0.0005), whereas no association was observed with lumbar spine osteophytes. No significant association between thoracic spine DSN or osteophytes and urinary CTX\u2010II levels was observed. Multivariate analysis of variance showed that, after adjustment for age and BMI, lumbar spine DSN (<jats:italic>P<\/jats:italic> = 0.0049), knee OA (<jats:italic>P<\/jats:italic> = 0.0055), and clinical hand OA (<jats:italic>P<\/jats:italic> = 0.0060) were, independently of each other, associated with CTX\u2010II levels. Thus, patients with lumbar spine DSN, knee OA, and clinical hand OA had CTX\u2010II levels 80% higher (<jats:italic>P<\/jats:italic> &lt; 0.0001 after adjustment for age and BMI) than those of patients with no lumbar spine DSN, no radiologic knee OA, and no clinical hand OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postmenopausal women with lumbar spine disc degeneration are characterized by increased CII degradation. The contribution of lumbar spine DSN to CII degradation was similar to, and independent of, the contribution of radiologic knee OA or clinical hand OA. Lumbar spine disc degeneration in elderly patients should be assessed when analyzing levels of CTX\u2010II in studies of knee, hip, and hand OA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20493","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T21:01:26Z","timestamp":1097269286000},"page":"3137-3144","source":"Crossref","is-referenced-by-count":63,"title":["Association between spine disc degeneration and type II collagen degradation in postmenopausal women: The OFELY study"],"prefix":"10.1002","volume":"50","author":[{"given":"Patrick","family":"Garnero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Sornay\u2010Rendu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Arlot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre D.","family":"Delmas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1480","volume-title":"Diagnosis of bone and joint disorders","author":"Resnick D","year":"1998"},{"key":"e_1_2_6_3_2","first-page":"1781","volume-title":"Rheumatology","author":"Dennison E","year":"2003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(03)00026-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119316"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118884"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<953::AID-ANR1>3.0.CO;2-Q"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200309000-00020"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10586"},{"key":"e_1_2_6_10_2","volume-title":"Osteoarthritis","author":"Poole AR","year":"2003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117156"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(00)00302-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11326"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00504-X"},{"issue":"9","key":"e_1_2_6_15_2","first-page":"S258","article-title":"Urinary type II collagen neoepitope (uTIINE) in osteoarthritis (OA) patients is associated with disease severity","volume":"42","author":"Woodworth TG","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"9","key":"e_1_2_6_16_2","first-page":"S249","article-title":"Measurement of urinary type II collagen neoepitope (uTIINE) levels in rheumatoid arthritis (RA) patients to assess joint status","volume":"42","author":"Saltarelli MJ","year":"1999","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11281"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11331"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10576"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.10.939"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10616"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110307"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.10.1789"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.4.332"},{"key":"e_1_2_6_25_2","first-page":"1911","article-title":"Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar spine degeneration","volume":"20","author":"Lane NE","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0603-z"},{"key":"e_1_2_6_27_2","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman RD","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.4.220"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.11.867"},{"key":"e_1_2_6_30_2","first-page":"932","article-title":"A longitudinal study of the effect of spinal degenerative disease on bone density in the elderly","volume":"22","author":"Jones G","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02652563"},{"key":"e_1_2_6_32_2","first-page":"842","article-title":"The distribution, determinants, and clinical correlates of vertebral osteophytosis: a population based survey","volume":"26","author":"O'Neill TW","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11321"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.6.619"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(00)00218-9"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/16.1.22"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1729::AID-ANR23>3.0.CO;2-H"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.4.246"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.01.003"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.20493","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.20493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T13:04:55Z","timestamp":1700744695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.20493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1002\/art.20493"],"URL":"https:\/\/doi.org\/10.1002\/art.20493","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}