{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:11:07Z","timestamp":1792030267010,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Aside from congenital heart block (CHB), sinus bradycardia and prolongation of the corrected QT (QTc) interval have been reported in infants born to mothers with anti\u2010SSA antibodies. To assess the pathologic nature of these manifestations, this study focused on electrocardiographic (EKG) variations in these children, comparing them with findings in a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 165 consecutive pregnancies in 106 anti\u2010SSA\u2013positive women with connective tissue diseases (CTDs). EKGs obtained on 58 children of this group were compared with those obtained on 85 infants born to mothers with CTD who were negative for both anti\u2010SSA and anti\u2010SSB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant difference was seen between the 2 study groups with regard to gestational age, prematurity, birth weight, age of the children at the time of EKG, age of the mothers, or treatments received by the mothers during their pregnancies. Seven of 137 children developed cutaneous neonatal lupus syndrome; 1 child developed CHB (CHB risk of 1 in 99 [1%] if only the first prospectively observed pregnancy in women without a history of CHB is included in the analysis). For EKGs recorded during the first 2 months of life, the mean \u00b1 SD PR interval was 96 \u00b1 16 msec in the anti\u2010SSA\u2013positive group and 96 \u00b1 13 msec in the anti\u2010SSA\u2013negative group (\n                      <jats:italic>P =<\/jats:italic>\n                      0.84), with mean QTc values of 397 \u00b1 27 and 395 \u00b1 25 msec (\n                      <jats:italic>P =<\/jats:italic>\n                      0.57) and mean heart rates of 141 \u00b1 23 and 137 \u00b1 21 beats per minute (\n                      <jats:italic>P =<\/jats:italic>\n                      0.20), respectively. No difference in the PR interval, QTc interval, or heart rate was observed for EKGs obtained between 2 and 4 months of life. When EKGs obtained at 0\u20132 months were compared with those obtained at 2\u20134 months, a physiologic prolongation of the QTc interval was observed in both study groups. No sudden infant death or symptomatic arrhythmia occurred during the first year of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The EKG findings in children of anti\u2010SSA\u2013positive and anti\u2010SSA\u2013negative mothers were not significantly different. Our results suggest that the prolongation of the QTc interval and sinus bradycardia that have recently been reported in children of mothers with anti\u2010SSA antibodies occur independently of the anti\u2010SSA antibodies. The pathologic nature of these EKG variations was not confirmed by our controlled study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.20554","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T17:03:22Z","timestamp":1097255002000},"page":"3187-3194","source":"Crossref","is-referenced-by-count":164,"title":["Outcome of pregnancies in patients with anti\u2010SSA\/Ro antibodies: A study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control 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