{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:19:16Z","timestamp":1791328756881,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T00:00:00Z","timestamp":1105056000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Anti\u2013cyclic citrullinated peptide (anti\u2010CCP) antibodies have been detected in patients with juvenile rheumatoid arthritis (JRA), particularly in those with polyarticular, rheumatoid factor (RF)\u2010positive JRA. Our objectives were to determine whether anti\u2010CCP antibodies are associated with HLA\u2013DR4 in children with polyarticular JRA, whether anti\u2010CCP antibodies are associated with clinical features of disease, and whether affected sibling pairs (ASPs) with JRA are concordant for this antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stored serum samples obtained from 230 HLA\u2010typed patients with JRA (77 with polyarticular\u2010onset disease and 153 with pauciarticular\u2010 or systemic\u2010onset disease), 100 JRA ASPs, and 688 healthy children were tested for anti\u2010CCP antibodies and RF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen percent of the patients with polyarticular\u2010onset JRA and 2% of the other JRA patients exhibited anti\u2010CCP antibodies, compared with only 0.6% of the controls. Fifty\u2010seven percent of RF\u2010positive patients with polyarticular\u2010onset JRA had anti\u2010CCP antibodies. HLA\u2013DR4\u2013positive patients with polyarticular\u2010onset JRA were more likely to have anti\u2010CCP antibodies than were those without HLA\u2013DR4 alleles (odds ratio [OR] 5.20, 95% confidence interval [95% CI] 1.30\u201320.9). Anti\u2010CCP antibodies were associated with polyarticular onset (OR 7.46, 95% CI 1.99\u201328.0), a polyarticular disease course (OR 9.78, 95% CI 1.25\u201376.7), and erosive disease (OR 14.3, 95% CI 3.01\u201367.9). Concordance rates for anti\u2010CCP antibodies among ASPs were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate increased anti\u2010CCP antibody formation in HLA\u2013DR4\u2013positive patients with polyarticular\u2010onset JRA. The overall prevalence of anti\u2010CCP antibodies in JRA is low, but a substantial proportion of RF\u2010positive patients with polyarticular\u2010onset JRA have these antibodies. Anti\u2010CCP antibodies in JRA are associated with polyarticular onset, a polyarticular course, and erosive disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20773","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T21:49:30Z","timestamp":1105134570000},"page":"239-246","source":"Crossref","is-referenced-by-count":66,"title":["Antibodies against cyclic citrullinated peptide are associated with HLA\u2013DR4 in simplex and multiplex polyarticular\u2010onset juvenile rheumatoid arthritis"],"prefix":"10.1002","volume":"52","author":[{"given":"Elizabeth D.","family":"Ferucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy S.","family":"Majka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lezlie A.","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta B.","family":"Moroldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Passo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Deane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Rewers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Arend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Michael","family":"Holers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_2_5_3_2","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997","volume":"25","author":"Petty RE","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.6.464"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341009"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222468"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11223"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20044"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.23.4.302"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(94)90088-4"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117969"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1316"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.4177"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1149"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3"},{"key":"e_1_2_5_17_2","first-page":"383","article-title":"Anticitrullinated protein\/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis","volume":"60","author":"Van Venrooij WJ","year":"2002","journal-title":"Neth J Med"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.608"},{"key":"e_1_2_5_19_2","first-page":"825","article-title":"Anti\u2010cyclic citrullinated peptide (anti\u2010CCP) antibodies in children with juvenile idiopathic arthritis","volume":"30","author":"Van Rossum M","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar93"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.10.1082"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401107"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20292"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199909)42:9<1843::AID-ANR8>3.0.CO;2-M"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050514"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.538"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20659"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.20773","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.20773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T03:22:52Z","timestamp":1700709772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.20773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1002\/art.20773"],"URL":"https:\/\/doi.org\/10.1002\/art.20773","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}