{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:07:39Z","timestamp":1789913259433,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T00:00:00Z","timestamp":1105056000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Uveitis or intraocular inflammation is a major cause of visual loss. Acute anterior uveitis (AAU) affects \u223c40% of patients with ankylosing spondylitis (AS) but also affects patients with no evidence of spondylarthritis. We sought to determine whether a unique genetic region could be implicated in a specific manifestation\u2014AAU\u2014of a multisystem, inflammatory, genetically complex disease, AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals from families multiplex for AAU were genotyped at 400 markers representing the ABI PRISM linkage map MD\u201010, and at the HLA\u2013B, DRB1, DQA1, DQB1, and DPB1 alleles. Among the family members with AAU, 76 affected sibpairs were analyzed (6 without concomitant AS, 12 discordant for AS, and 58 concordant for AS). Two\u2010point and multipoint nonparametric linkage analyses were performed, and 1\u2010parameter allele\u2010sharing model logarithm of odds (LOD) scores were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As previously reported for AS, linkage at the major histocompatibility complex region (chromosome 6p21) was evident, exhibiting the highest multipoint LOD score (4.96 at marker HLA\u2013B). Strong linkage was seen at a region on chromosome 9p21\u20139p24, with a LOD score of 3.72 at marker D9S157. When compared with a companion cohort of AS families, the linkage at this region was found in association with AAU but not with AS. A third region on chromosome 1q23\u20131q31 was observed to have suggestive linkage (LOD 2.05 at marker D1S238), which overlaps with a region associated with AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study in which a genetic region for AAU has been identified by genome\u2010wide scan. Even though AS was highly prevalent in this cohort of families, a locus at chromosome 9p21\u20139p24 was identified that uniquely associates with AAU. Identifying the genetic perturbation at this region may advance our understanding of the mechanisms involved in tissue\u2010specific pathology of complex inflammatory diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20777","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T22:41:46Z","timestamp":1105137706000},"page":"269-274","source":"Crossref","is-referenced-by-count":48,"title":["A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease"],"prefix":"10.1002","volume":"52","author":[{"given":"Tammy M.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudy M.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M.","family":"Rajska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Coffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias D.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Mackensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph D.","family":"Levinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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Kevin","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Reveille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/242121a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881403"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199804)41:4<588::AID-ART5>3.0.CO;2-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20308"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/319509"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00163549"},{"key":"e_1_2_6_9_2","first-page":"792","article-title":"Characterization of uveitis associated with spondyloarthritis","volume":"16","author":"Rosenbaum JT","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0889-857X(21)00714-6","article-title":"Acute anterior uveitis and spondyloarthropathies","volume":"18","author":"Rosenbaum JT","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.7.766"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(91)90005-Z"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91090-8"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1356::AID-ANR20>3.0.CO;2-Y"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000484736"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/301904"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/301592"},{"key":"e_1_2_6_19_2","first-page":"506","article-title":"Transmission test for linkage disequilibrium: the insulin gene region and insulin\u2010dependent diabetes mellitus (IDDM)","volume":"52","author":"Spielman RS","year":"1993","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/302957"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.10252"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320570319"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.6.1379"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.6.3940"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079107"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079114"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11106"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10329"},{"key":"e_1_2_6_30_2","first-page":"2470","article-title":"The Crohn's associated NOD2 3020InsC frameshift mutation does not confer susceptibility to ankylosing spondylitis","volume":"29","author":"D'Amato M","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_31_2","first-page":"102","article-title":"Lack of association of ankylosing spondylitis with the most common NOD2 susceptibility alleles to Crohn's disease","volume":"30","author":"Ferreiros\u2010Vidal I","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10196"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363914"}],"container-title":["Arthritis &amp; 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