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We previously identified elevated levels of oxidized low\u2010density lipoprotein (OxLDL) together with elevated levels of autoantibodies related to OxLDL as risk factors for cardiovascular disease in female patients with SLE. Autoantibodies to OxLDL are common in SLE and cross\u2010react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred forty\u2010seven female patients with SLE and 60 age\u2010 and sex\u2010matched controls were compared. A monoclonal antibody to oxidized phospholipids, EO6, was used to determine oxidation epitopes on LDL. Anti\u2010OxLDL and autoantibodies to malondialdehyde (MDA)\u2013modified LDL, cardiolipin, and oxidized aCL were determined by chemiluminescence technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As determined by binding of EO6, patients with SLE had a higher level of oxidized phospholipids on LDL (<jats:italic>P<\/jats:italic> = 0.005) compared with controls. The level of OxLDL (e.g., oxidized phospholipid\/apolipoprotein B) was associated with arterial disease (<jats:italic>P<\/jats:italic> = 0.006) and renal manifestations (<jats:italic>P<\/jats:italic> = 0.04). As reported previously, levels of aCL, autoantibodies to OxLDL, and autoantibodies to MDA\u2010modified LDL were enhanced and were closely correlated in SLE. Anticardiolipin antibodies from these SLE patients recognized mainly oxidized forms of cardiolipin, indicating that antigenic epitopes on cardiolipin are related to lipid peroxidation in patients with SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In general, patients with SLE (particularly those with cardiovascular disease) had more oxidized epitopes on LDL compared with controls. Furthermore, aCL in these patients recognized epitopes generated during lipid peroxidation. Thus, \u201cneo\u201d self antigens on lipoproteins, generated during oxidation, are present in SLE and may be of importance for the development of premature cardiovascular disease and possibly also for other autoimmune phenomena observed in SLE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20780","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T22:32:43Z","timestamp":1105137163000},"page":"192-200","source":"Crossref","is-referenced-by-count":206,"title":["Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease 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