{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:06:30Z","timestamp":1777647990030,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Beh\u00e7et's disease is a chronic, relapsing, multisystemic inflammatory disorder characterized by recurrent oral and genital ulcers and by ocular, articular, vascular, and central nervous system involvement. The tumor necrosis factor \u03b1 (TNF\u03b1) pathway is likely involved in the pathophysiology of Beh\u00e7et's disease. One of the 2 TNF\u03b1 receptors is TNF receptor superfamily 1A (TNFRSF1A). We searched for R92Q <jats:italic>TNFRSF1A<\/jats:italic> mutations in patients with Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search for <jats:italic>TNFRSF1A<\/jats:italic> mutations was performed by polymerase chain reaction amplification of the TNFRSF1A gene, followed by denaturing high\u2010performance liquid chromatography scanning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 74 unrelated European patients with Beh\u00e7et's disease, 5 (6.8%) carried the R92Q <jats:italic>TNFRSF1A<\/jats:italic> mutation. The frequency of the R92Q mutation in patients with Beh\u00e7et's disease was significantly higher than that in controls (<jats:italic>P<\/jats:italic> = 0.006 by Fisher's exact test). Deep vein thrombosis was significantly associated with the R92Q mutation (<jats:italic>P<\/jats:italic> = 0.001 [with Bonferroni adjustment for multiple comparisons]). Among the 30 patients with thrombosis, 10 had cerebral thrombophlebitis. None of these patients had the R92Q mutation. Among the 20 patients with Beh\u00e7et's disease who had extracranial deep vein thrombosis, 6 had the R92Q mutation, whereas 14 did not (<jats:italic>P<\/jats:italic> &lt; 0.0001)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The R92Q mutation in patients with Beh\u00e7et's disease is associated with an increased risk of extracranial venous thrombosis. This new finding may help in understanding the complex prothrombotic state in patients with Beh\u00e7et's disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20873","type":"journal-article","created":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T22:56:27Z","timestamp":1107471387000},"page":"608-611","source":"Crossref","is-referenced-by-count":58,"title":["Association of the R92Q <i>TNFRSF1A<\/i> mutation and extracranial deep vein thrombosis in patients with Beh\u00e7et's disease"],"prefix":"10.1002","volume":"52","author":[{"given":"Zahir","family":"Amoura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Dod\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Hue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Caillat\u2010Zucman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiamak","family":"Bahram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Delpech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Grateau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Charles","family":"Piette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease","volume":"335","author":"International Study Group for Behcet's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380321"},{"key":"e_1_2_6_4_2","volume-title":"Immunology of Behcet's disease","author":"Ziehrut M","year":"2003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-6-199803150-00004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-10-199605150-00005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.suppl_2.ii51"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00057-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.12.1487"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200209000-00002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10429"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201143"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19284"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018061"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074049"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01137-2"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.20873","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.20873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:33:59Z","timestamp":1697049239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.20873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1002\/art.20873"],"URL":"https:\/\/doi.org\/10.1002\/art.20873","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}