{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:02:52Z","timestamp":1790254972468,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine laboratory parameters that may be useful in identifying polymyalgia rheumatica (PMR) patients who require long\u2010term corticosteroid therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective followup study of 94 consecutive untreated patients with PMR were assessed for relapse\/recurrence for a mean of 39 months. This cohort represented all the patients diagnosed over a 4\u2010year period in 2 Italian secondary referral centers. Patients were monitored for clinical signs and symptoms, erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP), and serum interleukin\u20106 (IL\u20106). IL\u20106 levels were also measured in 43 controls matched to the patients for age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ESR was elevated in 91.5% of the patients prior to therapy initiation, as were CRP in 98.9% and serum IL\u20106 in 92.6%. Forty\u2010seven (50.0%) patients had at least 1 relapse\/recurrence during the followup period and 24 (25.5%) had at least 2. After 4 weeks of prednisone therapy, ESR was elevated in 13.2% patients, CRP in 41.9%, and serum IL\u20106 in 37.2%. IL\u20106 levels remained persistently elevated in 9.9% and CRP in 8.7% of patients during the first year of followup, whereas no patient had persistently elevated ESR. Persistently elevated CRP and IL\u20106 levels were significantly associated with an increased risk of relapse\/recurrence. In particular, patients with persistently elevated levels of IL\u20106 during the first year of therapy had the highest relative risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the control of clinical symptoms, corticosteroids do not adequately control the inflammatory process in a subset of patients with PMR who have persistently elevated levels of CRP and IL\u20106 and who have a higher risk of relapsing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20901","type":"journal-article","created":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T18:18:26Z","timestamp":1107541106000},"page":"33-38","source":"Crossref","is-referenced-by-count":139,"title":["Acute\u2010phase reactants and the risk of relapse\/recurrence in polymyalgia rheumatica: A prospective followup 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