{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:25:14Z","timestamp":1791221114729,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To register all newly diagnosed patients with primary systemic vasculitides (PSV) in a large region in northern Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 1, 1998 and December 31, 2002 all newly diagnosed cases of PSV were identified in a large mixed rural\/urban northern German region consisting of 2,777,275 habitants in a population\u2010based prospective study. The following sources were used: departments of all hospitals, including their outpatient clinics; all departments of pathology; and the reference immunologic labs serving the catchment area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 5 years, 642 PSV patients were identified. The incidence rates for all PSV were between 40 and 54 cases per 1 million and per year. People at age 50 years and older had a 3\u20135\u2010fold higher risk of developing PSV compared with those younger than 50 years. The incidence rates of antineutrophil cytoplasmic antibody (ANCA)\u2013associated PSV (Wegener's granulomatosis [WG], microscopic polyangiitis [MPA], Churg\u2010Strauss syndrome [CSS]) were between 9.5 and 16\/million\/year. WG occured 2\u20133 times more frequently than MPA or CSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results of a population\u2010based vasculitis register over 5 years for the incidence of PSV among 2.78 million habitants in northern Germany revealed a stable incidence for all PSV. Compared with other European studies coming from small regions or referral centers, the incidence rates for ANCA\u2010associated PSV were the same as in Norway, lower than those in United Kingdom, but higher than those in Spain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20928","type":"journal-article","created":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T18:20:08Z","timestamp":1107541208000},"page":"93-99","source":"Crossref","is-referenced-by-count":241,"title":["Stable incidence of primary systemic vasculitides over five years: Results from the German vasculitis register"],"prefix":"10.1002","volume":"53","author":[{"given":"Eva","family":"Reinhold\u2010Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Herlyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Wagner\u2010Bastmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11115"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01450893"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00324.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.2.170"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-3-199508010-00006"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.2.142"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.1.23"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2481::AID-ANR15>3.0.CO;2-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370705"},{"key":"e_1_2_6_11_2","first-page":"273","article-title":"Giant cell arteritis and polymyalgia rheumatica in a region of Finland: an epidemiologic, clinical and pathologic study, 1984\u20131988","volume":"19","author":"Franzen P","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.4.367"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310607"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.10.938"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390112"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.12.1396"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.5.540"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380415"},{"key":"e_1_2_6_20_2","first-page":"685","article-title":"Incidence studies of systemic lupus erythematosus in southern Sweden: increasing age, decreasing frequency of renal manifestations and good prognosis","volume":"27","author":"Stahl\u2010Hallengren C","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199901)42:1<46::AID-ANR6>3.0.CO;2-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4412"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400309"},{"key":"e_1_2_6_24_2","first-page":"73","article-title":"The epidemiology of morphea (localized scleroderma) in Olmsted County 1960\u20131993","volume":"24","author":"Peterson LS","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330812"},{"key":"e_1_2_6_26_2","first-page":"427","article-title":"Wegener's granulomatosis: a series of 265 British cases seen between 1975 and 1985: a report by a sub\u2010committee of the British Thoracic Society Research Committee","volume":"83","author":"Anderson G","year":"1992","journal-title":"QJM"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-488"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)80066-0"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<1021::AID-ANR10>3.0.CO;2-J"}],"container-title":["Arthritis Care &amp; 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