{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:34:07Z","timestamp":1792056847437,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T00:00:00Z","timestamp":1109894400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the influence of the genetic background of an arthritis\u2010prone strain of mice, MRL, on the spontaneous development of arthropathy in DBA\/1 mice, which histopathologically resembles enthesopathy in humans, and to clarify the strain\u2010specific gene loci and their interactions that confer susceptibility to arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MRL, DBA\/1, (MRL \u00d7 DBA\/1)F<jats:sub>1<\/jats:sub>, and (MRL \u00d7 DBA\/1)F<jats:sub>2<\/jats:sub> intercross mice were prepared, and the severity and onset of arthropathy of the ankle joints in individual mice were quantified (0\u20133 and 0\u20135 scale, respectively). A genome\u2010wide scan of 271 male F<jats:sub>2<\/jats:sub> intercross mice with polymorphic microsatellite markers was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only male DBA\/1, (MRL \u00d7 DBA\/1)F<jats:sub>1<\/jats:sub>, and (MRL \u00d7 DBA\/1)F<jats:sub>2<\/jats:sub> mice developed arthropathy. The macroscopic and histopathologic findings of arthropathy in the F<jats:sub>2<\/jats:sub> mice were similar to those in the parental DBA\/1 mice, but the onset was significantly earlier. In the quantitative trait locus analysis of male F<jats:sub>2<\/jats:sub> mice, 1 susceptibility locus for both the severity and early onset of the disease in the region of an MRL allele, <jats:italic>Amd1<\/jats:italic>, was located at marker <jats:italic>D10Mit259<\/jats:italic> (map position 40.0 cM), which was common to 1 of the sialadenitis susceptibility loci in MRL mice, <jats:italic>Asm1<\/jats:italic>. Another susceptibility locus for the severity and early onset of arthropathy in the region of a DBA allele, <jats:italic>Amd2<\/jats:italic>, was located at <jats:italic>D3Mit46<\/jats:italic> (29.5 cM). These loci manifested an additive effect on the development of arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Arthropathy in DBA\/1 mice is under the control of an allelic combination of gene loci, one of which is common to the locus for sialadenitis in MRL\/MpJ\u2010<jats:italic>lpr<\/jats:italic>\/<jats:italic>lpr<\/jats:italic> mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.20956","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T15:51:40Z","timestamp":1109951500000},"page":"959-966","source":"Crossref","is-referenced-by-count":14,"title":["Accelerating effect of an MRL gene locus on the severity and onset of arthropathy in DBA\/1 mice"],"prefix":"10.1002","volume":"52","author":[{"given":"Hisashi","family":"Oishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Mizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Kamogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Tsubaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Arita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyasu","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"207","volume-title":"Genetic control of autoimmune disease","author":"Murphy ED","year":"1978"},{"key":"e_1_2_6_3_2","first-page":"154","article-title":"Genetic basis of autoimmune disease in MRL\/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci","volume":"2","author":"Nose M","year":"2000","journal-title":"Rev Immunogenet"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-714"},{"key":"e_1_2_6_6_2","first-page":"271","article-title":"Analysis of granulomatous arteritis in MRL\/Mp autoimmune disease mice bearing lymphoproliferative genes: the use of mouse genetics to dissociate the development of arteritis and glomerulonephritis","volume":"135","author":"Nose M","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199912)42:12<2616::AID-ANR16>3.0.CO;2-O"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<2027::AID-IMMU2027>3.0.CO;2-S"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10193"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10952"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.3.688"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06473.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350619"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<844::AID-ANR15>3.0.CO;2-B"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2210"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(87)90010-3"},{"key":"e_1_2_6_17_2","unstructured":"1994 Organizing Committee 5th World Congress on Genetics Applied to Livestock Production Guelph (Canada) CJ Basten BS Weir ZB Zeng C Smith JS Gavora B Benkel J Chesnais W Fairfull JP Gibson Zmap: a QTL cartographer 65 74"},{"key":"e_1_2_6_18_2","volume-title":"Windows QTL cartographer, version 2.0. 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