{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:23:27Z","timestamp":1793755407355,"version":"4.6.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify novel autoantibodies specific for dermatomyositis (DM), especially those specific for clinically amyopathic DM (C\u2010ADM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Autoantibodies were analyzed by immunoprecipitation in 298 serum samples from patients with various connective tissue diseases (CTDs) or idiopathic pulmonary fibrosis (IPF). Antigen specificity of the sera was further examined by immunoblotting and indirect immunofluorescence (IF). The disease specificity and clinical features associated with the antibody of interest were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight sera recognized a polypeptide of \u223c140 kd (CADM\u2010140 autoantigen) by immunoprecipitation and immunoblotting. Immunoreactivity was detected in the cytoplasm, and indirect IF revealed a granular or reticular pattern. Anti\u2013CADM\u2010140 antibodies were detected in 8 of 42 patients with DM, but not in patients with other CTDs or IPF. Interestingly, all 8 patients with anti\u2013CADM\u2010140 antibodies had C\u2010ADM. Among 42 patients with DM, those with anti\u2013CADM\u2010140 autoantibodies had significantly more rapidly progressive interstitial lung disease (ILD) when compared with patients without anti\u2013CADM\u2010140 autoantibodies (50% versus 6%; <jats:italic>P<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that the presence of anti\u2013CADM\u2010140 autoantibodies may be a novel marker for C\u2010ADM. Further attention should be directed to the detection of rapidly progressive ILD in those patients with anti\u2013CADM\u2010140 autoantibodies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21023","type":"journal-article","created":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T06:47:13Z","timestamp":1115362033000},"page":"1571-1576","source":"Crossref","is-referenced-by-count":660,"title":["Autoantibodies to a 140\u2010kd polypeptide, CADM\u2010140, in Japanese patients with clinically amyopathic dermatomyositis"],"prefix":"10.1002","volume":"52","author":[{"given":"Shinji","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michito","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Suwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyo","family":"Mimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeji","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester V.","family":"Oddis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-9-199505010-00010"},{"key":"e_1_2_6_3_2","first-page":"742","volume-title":"Arthritis and allied conditions","author":"Pearson CM","year":"1997"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350415"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330908"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780280711"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120621"},{"key":"e_1_2_6_8_2","first-page":"204","article-title":"Two cases of amyopathic dermatomyositis with fatal rapidly progressive interstitial pneumonitis","volume":"30","author":"Tokiyama K","year":"1990","journal-title":"Ryumachi"},{"issue":"9","key":"e_1_2_6_9_2","first-page":"S194","article-title":"Autoantibodies to 155 kD and Se antigens in patients with clinically\u2010amyopathic dermatomyositis","volume":"43","author":"Targoff IN","year":"2000","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.4.2315"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107688908200607"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00032-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.35"},{"issue":"9","key":"e_1_2_6_15_2","first-page":"S139","article-title":"Clinical and serological characterization of the anti\u2010MJ antibody in childhood myositis","volume":"40","author":"Oddis CV","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"9","key":"e_1_2_6_16_2","first-page":"S140","article-title":"Serum autoantibodies in juvenile idiopathic inflammatory myopathies (IIM) in a cohort of Argentine patients","volume":"40","author":"Espada G","year":"1997","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.21023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.21023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T03:41:52Z","timestamp":1696995712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.21023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/art.21023"],"URL":"https:\/\/doi.org\/10.1002\/art.21023","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}