{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:49:39Z","timestamp":1791269379614,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The protein tyrosine phosphatase N22 (<jats:italic>PTPN22<\/jats:italic>) gene exhibits regulatory activities for both T cells and B cells. A missense single\u2010nucleotide polymorphism (SNP) within this gene (rs2476601) has recently been associated with 4 autoimmune diseases: rheumatoid arthritis (RA), systemic lupus erythematosus, autoimmune thyroid disease, and type 1 diabetes mellitus, all of which are T cell\u2013mediated and associated with the elaboration of autoantibody. The aim of this study was to investigate associations of the missense SNP of <jats:italic>PTPN22<\/jats:italic> in a number of autoimmune diseases in the UK population, including RA, juvenile idiopathic arthritis (JIA), psoriasis, psoriatic arthritis (PsA), and multiple sclerosis (MS), some of which have not been examined previously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:italic>PTPN22<\/jats:italic> missense SNP was genotyped in 886 RA, 661 JIA, 279 psoriasis, 455 PsA, and 379 MS patients and in 595 healthy controls. Association with the <jats:italic>PTPN22<\/jats:italic> SNP was analyzed by chi\u2010square test as implemented in Stata software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant association between the <jats:italic>PTPN22<\/jats:italic> SNP and RA (<jats:italic>P<\/jats:italic> = 1.8 \u00d7 10<jats:sup>\u20138<\/jats:sup>) and JIA (<jats:italic>P<\/jats:italic> = 0.0005). In contrast, no association with psoriasis, PsA, or MS was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We replicated the findings of a previous association with RA and identified a novel association with JIA. Together with previous data showing associations with other autoimmune diseases, our findings provide further evidence that the <jats:italic>PTPN22<\/jats:italic> gene plays a role in the pathogenesis of a subgroup of autoimmune diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21049","type":"journal-article","created":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T13:06:04Z","timestamp":1117803964000},"page":"1694-1699","source":"Crossref","is-referenced-by-count":248,"title":["Association between the <i>PTPN22<\/i> gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: Further support that <i>PTPN22<\/i> is an autoimmunity gene"],"prefix":"10.1002","volume":"52","author":[{"given":"Anne","family":"Hinks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E. 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