{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:49:30Z","timestamp":1790102970327,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T00:00:00Z","timestamp":1119916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus\u2013associated end\u2010organ disease in hosts with an underlying autoimmune diathesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We introduced a BAFF transgene (Tg) into autoimmune\u2010prone B6.Sle1 and B6.Nba2 mice and evaluated these mice for serologic autoimmunity and renal pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>B6.Sle1.BAFF and B6.Nba2.BAFF mice, but not non\u2010Tg littermates, frequently developed severe glomerular pathology by 3 months of age. Age\u2010matched B6.BAFF mice, despite renal Ig deposits and increases in B cells and Ig production similar to those in B6.Sle1.BAFF and B6.Nba2.BAFF mice, did not develop glomerular pathology. In B6.Sle1.BAFF and B6.Nba2.BAFF mice, severity of glomerular disease did not obligately correlate with circulating levels of IgG antichromatin and\/or anti\u2013double\u2010stranded DNA antibodies or with amounts of these autoantibodies deposited in the kidneys. Even in mice with severe glomerular disease, renal tubulointerstitial infiltrates were very limited, and increased proteinuria was not detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BAFF\u2010driven effects on glomerular pathology may be mediated, at least in part, by autoantibodies with specificities other than chromatin and\/or by autoantibody\u2010independent means. There is an uncoupling of BAFF\u2010driven precocious glomerular pathology from concomitant development of clinically apparent renal disease, strongly suggesting that BAFF overexpression works in concert with other factors to promote overt renal disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21138","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T15:50:11Z","timestamp":1119973811000},"page":"2080-2091","source":"Crossref","is-referenced-by-count":101,"title":["BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus"],"prefix":"10.1002","volume":"52","author":[{"given":"William","family":"Stohl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung 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