{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:13:51Z","timestamp":1791900831000,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T00:00:00Z","timestamp":1122508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the use of a novel surface coil for clinically utilized magnetic resonance imaging (MRI) scanners, in order to describe the microanatomic basis for hand osteoarthritis (OA) at all stages of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MRI of proximal or distal interphalangeal joints was performed in 58 subjects: 16 patients with early OA (symptom duration \u226412 months), 14 patients with chronic OA, 10 patients with clinically normal asymptomatic joints adjacent to arthritic joints, and 18 normal controls. High\u2010resolution images were obtained with displayed pixel dimensions of 80\u2013100 \u03bcm using a 1.5T scanner and a 23\u2010mm\u2013diameter surface coil. All joint structures were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The high\u2010resolution images of every joint structure showed comparable abnormalities in both early and chronic OA, including cartilage loss, bone edema, synovial enhancement, osteophytosis, and erosions. Heberden's and Bouchard's node formation occurred at regions where soft tissue bulged through the capsule between the dorsal tendons and collateral ligaments (CLs). Prominent CL thickening or disruption (100% of OA patients) was evident even in joints where cartilage was partially preserved. Clinically normal joints adjacent to OA hand joints showed thickening and enhancement of CLs which was the most common abnormality seen (80% of OA patients). Older normal subjects showed subtle changes within the CLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obtaining high\u2010resolution MR images from clinically utilized scanners represents a novel way for exploring the microanatomic basis of hand arthritis and may have considerable potential in the clinical setting. In the present evaluation in nodal OA, previously unappreciated CL abnormalities were especially common.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21210","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T19:11:23Z","timestamp":1122577883000},"page":"2355-2365","source":"Crossref","is-referenced-by-count":152,"title":["High\u2010resolution magnetic resonance imaging for the assessment of hand osteoarthritis"],"prefix":"10.1002","volume":"52","author":[{"given":"Ai Lyn","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Grainger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Shelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Pease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20051"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20136"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7194.1299"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-7-200104030-00007"},{"key":"e_1_2_6_6_2","first-page":"1330","article-title":"Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis","volume":"28","author":"Hill CL","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.3.1790657"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg110"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.8.535"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(96)80053-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.5.1013"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199901)42:1<119::AID-ANR15>3.0.CO;2-A"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.22.2.g02mr11237"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10018"},{"key":"e_1_2_6_15_2","first-page":"77","article-title":"The importance of subchondral bone in the progression of osteoarthritis","volume":"70","author":"Burr DB","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.11.675"},{"key":"e_1_2_6_17_2","first-page":"436","article-title":"Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair","volume":"18","author":"Brandt KD","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02030082"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.008136"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2106\/00004623-200402000-00001","article-title":"Ligament reconstruction with or without tendon interposition to treat primary thumb carpometacarpal osteoarthritis: a prospective randomized study","volume":"86","author":"Au G","year":"2004","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(86)80008-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20354"},{"key":"e_1_2_6_23_2","first-page":"799","article-title":"The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: the Chingford Study","volume":"30","author":"Dolan AL","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.8.540"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2004.02.009"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh129"}],"container-title":["Arthritis &amp; 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