{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:08:08Z","timestamp":1788671288928,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T00:00:00Z","timestamp":1122508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the incidence of cancer in patients with scleroderma (systemic sclerosis) and to compare those rates with cancer rates in the local population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cancer risk in scleroderma patients in the Detroit metropolitan area was assessed by linking patient identification codes of the Michigan Scleroderma Registry to the Metropolitan Detroit Cancer Surveillance System database. Patients were screened between the years 1973 and 2002, with additional followup to 2004. Standardized incidence ratios (SIRs) were calculated for selected malignancies (lung, liver, colon, breast, cervical, and prostate cancers, and non\u2010Hodgkin's lymphomas), with stratification by sex and race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 934 patients in the Scleroderma Registry, 538 were included in the study based on tri\u2010county residency (436 females and 102 males). Of these, 45 first malignancies were noted (37 females and 8 males). Lung cancer (10 cases) was found to be the most common cancer in scleroderma patients. However, its incidence was not significantly different from that in the general population of metropolitan Detroit (SIR 1.23). Other types of cancer were examined, and no significant differences were found as compared with the rates in the local population, with 1 exception: black females with scleroderma had significantly higher rates of liver cancer (SIR 45.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contrary to previous studies, this study did not find statistical evidence of an increased incidence of cancer in scleroderma patients, except for liver cancer. One possible reason is the high background rates of certain cancers in the metropolitan Detroit area. It may be necessary to consider local cancer rates when comparing different scleroderma cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.21225","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T22:46:56Z","timestamp":1122590816000},"page":"2415-2424","source":"Crossref","is-referenced-by-count":107,"title":["Risk of malignancy in scleroderma: A population\u2010based cohort study"],"prefix":"10.1002","volume":"52","author":[{"given":"Soumya","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Dombi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Severson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen D.","family":"Mayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.7.531"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360405"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950901)76:5<910::AID-CNCR2820760528>3.0.CO;2-T"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281204"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(97)80804-1"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0248-8663(96)82683-X"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.8.728"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350621"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90002-M"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(18)30752-3"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(80)90007-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.8.697"},{"key":"e_1_2_5_14_2","first-page":"1136","article-title":"Incidence of lung cancer in systemic sclerosis","volume":"12","author":"Golden M","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1278"},{"key":"e_1_2_5_16_2","first-page":"1161","article-title":"Bronchiolo\u2010alveolar carcinoma and scleroderma: report of a case and review of the literature","volume":"50","author":"Godeau P","year":"1974","journal-title":"Sem Hop"},{"key":"e_1_2_5_17_2","first-page":"102","article-title":"Bronchiolo\u2010alveolar carcinoma complicating systemic scleroderma under long\u2010term treatment with factor XIII","volume":"43","author":"Grivaux M","year":"1987","journal-title":"Rev Pneumol Clin"},{"key":"e_1_2_5_18_2","first-page":"109","article-title":"Bronchiolo\u2010alveolar carcinoma in the lung with scleroderma","volume":"11","author":"Cavazzini L","year":"1970","journal-title":"Riv Patol Clin Sper"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199401000-00017"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(05)80845-8"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1988.tb03394.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.1.65"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.24.155"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2340\/0001555565521525","article-title":"Hematologic disease in scleroderma syndromes","volume":"65","author":"Doyle JA","year":"1985","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01889012"},{"key":"e_1_2_5_26_2","first-page":"518","article-title":"Dysplastic Barrett's esophagus in scleroderma","volume":"80","author":"Sprung DJ","year":"1985","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.2.177"},{"issue":"9","key":"e_1_2_5_28_2","first-page":"S315","article-title":"Risk of malignancy in scleroderma [abstract]","volume":"43","author":"Chatterjee S","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"9","key":"e_1_2_5_29_2","first-page":"S150","article-title":"Prevalence, incidence and survival rates of systemic sclerosis in the Detroit metropolitan area [abstract]","volume":"39","author":"Mayes MD","year":"1996","journal-title":"Arthritis Rheum"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400903"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-000-0029-3"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11073"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_5_35_2","volume-title":"St. Anthony's ICD\u20109\u2010CM code book for physician payment","author":"Jones MD","year":"1996"},{"key":"e_1_2_5_36_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(68)90038-6"},{"key":"e_1_2_5_38_2","unstructured":"Metropolitan Detroit Cancer Surveillance System Web site. URL:http:\/\/www.karmanos.org\/epid\/."},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.1.55"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200009000-00019"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.2307\/2342435"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<444::AID-ANR27>3.0.CO;2-G"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010080014013"},{"key":"e_1_2_5_44_2","first-page":"1994","article-title":"Autoantibodies in patients with systemic sclerosis and cancer: a case\u2010control study","volume":"30","author":"erk CT","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_5_45_2","unstructured":"SEER cancer statistics review. Bethesda: National Cancer Institute;2004."}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.21225","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.21225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:20:36Z","timestamp":1697059236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.21225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,28]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1002\/art.21225"],"URL":"https:\/\/doi.org\/10.1002\/art.21225","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,28]]}}}