{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:56:03Z","timestamp":1790697363613,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T00:00:00Z","timestamp":1122508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Administration of anti\u2013tumor necrosis factor (anti\u2010TNF) agents is beneficial in a variety of chronic inflammatory conditions, including psoriasis. We describe 5 patients in whom psoriasiform skin lesions developed 6\u20139 months after the initiation of anti\u2010TNF therapy for longstanding, seropositive rheumatoid arthritis (etanercept or adalimumab), typical ankylosing spondylitis (infliximab), and Adamantiades\u2010Beh\u00e7et's disease (infliximab). In all 5 patients, the underlying disease had responded well to anti\u2010TNF therapy. Four patients developed a striking pustular eruption on the palms and\/or soles accompanied by plaque\u2010type psoriasis at other skin sites, while 1 patient developed thick erythematous scaly plaques localized to the scalp. In 3 patients there was nail involvement with onycholysis, yellow discoloration, and subungual keratosis. Histologic findings from skin biopsies were consistent with psoriasis. None of these patients had a personal or family history of psoriasis. In all patients, skin lesions subsided either with topical treatment alone, or after discontinuation of the responsible anti\u2010TNF agent. The interpretation of this paradoxical side effect of anti\u2010TNF therapy remains unclear but may relate to altered immunity induced by the inhibition of TNF activity in predisposed individuals.<\/jats:p>","DOI":"10.1002\/art.21233","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T23:22:00Z","timestamp":1122592920000},"page":"2513-2518","source":"Crossref","is-referenced-by-count":244,"title":["Psoriasis induced by anti\u2013tumor necrosis factor therapy: A paradoxical adverse reaction"],"prefix":"10.1002","volume":"52","author":[{"given":"P. P.","family":"Sfikakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iliopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Elezoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kittas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stratigos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,28]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020719"},{"issue":"2","key":"e_1_2_4_3_2","first-page":"87","article-title":"Psoriasis treatment: current and emerging directed therapies","volume":"64","author":"Winterfield LS","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-5-200403020-00025"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05717.x"},{"issue":"2","key":"e_1_2_4_7_2","first-page":"14","article-title":"Psoriatic arthritis: epidemiology, clinical features, course, and outcome","volume":"64","author":"Gladman DD","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C477"},{"key":"e_1_2_4_9_2","first-page":"439","article-title":"Pustular psoriasis induced by infliximab","volume":"3","author":"Thurber M","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20155"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06107.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.829"},{"key":"e_1_2_4_13_2","unstructured":"KaryS WormM FritzJ AudringH SchererHU LeeHH et al. New onset or aggravation of psoriatic skin lesions in patients with definite rheumatoid arthritis under treatment with TNF\u03b1 antagonists: report of eight cases [abstract]. European League Against Rheumatism: Annual European Congress of Rheumatology Berlin Germany June 9\u201312 2004. Abstract no. FRI0095. URL:www.eular.org."},{"key":"e_1_2_4_14_2","unstructured":"HaibelH RudwaleitM StrasserC SpillerI DornerT SieperJ. Unexpected new onset or exacerbation of psoriasis in treatment of active ankylosing spondylitis with TNF\u03b1\u2010blocking agents: four case reports [abstract]. European League Against Rheumatism: Annual European Congress of Rheumatology Berlin Germany June 9\u201312 2004. Abstract no. SAT0061. 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